Results 51 to 60 of about 2,081,819 (312)

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

Retrovirology, 2019
Background Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome.
Christine M. Fennessey, Celine Camus, Taina T. Immonen, Carolyn Reid, Frank Maldarelli, Jeffrey D. Lifson, Brandon F. Keele   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod- shaped virus 2 [PDF]

, 2014
Viruses infecting hyperthermophilic archaea typically do not encode DNA polymerases, raising questions regarding their genome replication. Here, using a yeast two-hybrid approach, we have assessed interactions between proteins of Sulfolobus islandicus ...
Gardner, A.F., Bell, S.D., Krupovic, M., Prangishvili, D., White, M.F., Bell, Stephen D., White, Malcolm F., Krupovic, Mart, Prangishvili, David, Gardner, Andrew F., White, M.F.; id_orcid   +10 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Transcriptome analysis of infection of the archaeon Sulfolobus solfataricus with Sulfolobus turreted icosahedral virus [PDF]

, 2008
Microarray analysis of infection by Sulfolobus turreted icosahedral virus (STIV) revealed insights into the timing and extent of virus transcription, as well as differential regulation of host genes. Using a microarray containing genes from both the host
Walther, Jasper, Douglas, Trevor, Brumfield, Susan K., Bothner, Brian, Ortmann, Alice C., McInnerney, Kathleen, Young, Mark J., Brouns, Stan J.J., Van De Werken, Harmen J.G.; id_orcid, Van De Oost, John, Van Der Oost, John, Werken, H.J.G., van de, Brumfield, S.K., Douglas, T., Oost, J., van der, Walther, J., Young, M.J., Ortmann, A.C., Brouns, S.J.J., Bothner, B., McInnerney, K.   +20 more
core   +1 more source

Virus replication

, 2016
To continue the chain of infection, a virus must undergo the process of replication to create new, infectious virions that are able to infect other cells of the body or subsequent hosts. After gaining entry into the body, a virus makes physical contact with and crosses the plasma membrane of a target cell.
openaire   +1 more source

Hepatitis C Virus Replication

Cold Spring Harbor Perspectives in Medicine, 2019
Replication and amplification of the viral genome is a key process for all viruses. For hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome requires the synthesis of a negative-sense RNA template, which is in turn used for the production of new genomic RNA. This process is governed by numerous proteins, both host and
Keisuke, Tabata, Christopher J, Neufeldt, Ralf, Bartenschlager   +2 more
openaire   +3 more sources

Hepatitis E Virus Replication [PDF]

Viruses, 2019
Hepatitis E virus (HEV) is a small quasi-enveloped, (+)-sense, single-stranded RNA virus belonging to the Hepeviridae family. There are at least 20 million HEV infections annually and 60,000 HEV-related deaths worldwide. HEV can cause up to 30% mortality in pregnant women and progress to liver cirrhosis in immunocompromised individuals and is ...
Robert LeDesma, Ila Nimgaonkar, Alexander Ploss   +2 more
openaire   +3 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression [PDF]

, 2005
Type 1 interferons (IFN-?/?) are key mediators of innate antiviral responses but havelittle effect on established replication of dengue viruses, which are mosquito-borneflaviviruses of immense global health importance.
Jones, M, Jacobs, M, Ball, S, Hibbert, L, Foster, G, Davidson, AD, Foster, GR, Davidson, A, Gruenwald, P, Schlaak, J   +9 more
core   +1 more source