Results 41 to 50 of about 509,253 (315)

DNA Virus Replication Compartments [PDF]

Journal of Virology, 2014
ABSTRACTViruses employ a variety of strategies to usurp and control cellular activities through the orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear compartments. Formation of such specialized virus-induced cellular microenvironments, which have been termed viroplasms, virus factories, or virus replication centers ...
Melanie, Schmid, Thomas, Speiseder, Thomas, Dobner, Ramon A, Gonzalez   +3 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Coalescence of the sites of cowpea mosaic virus RNA replication into a cytopathic structure

, 2002
Cowpea mosaic virus (CPMV) replication induces an extensive proliferation of endoplasmic reticulum (ER) membranes, leading to the formation of small membranous vesicles where viral RNA replication takes place.
Carette, J.E., Gühl, K., Wellink, J., Kammen, A., van   +3 more
core   +1 more source

The RNA Capping Enzyme Domain in Protein A is Essential for Flock House Virus Replication [PDF]

, 2018
The nodavirus flock house virus (FHV) and the alphavirus Semliki Forest virus (SFV) show evolutionarily intriguing similarities in their replication complexes and RNA capping enzymes. In this study, we first established an efficient FHV trans-replication
Ahola, Tero, Maija K. Pietilä, Yu Chen, Quirin, Tania, Tero Ahola, Guo, Deyin, Chen, Yu, Maija K. Pietilä, Deyin Guo, Tania Quirin, Pietilä, Maija K.   +10 more
core   +1 more source

The Replication of Semliki Forest Virus

Journal of General Virology, 1974
Summary Using polyacrylamide gel electrophoresis, column chromatography on CF11 cellulose and salt precipitation, together with ribonuclease treatment, we have identified, in chick cells infected with Semliki Forest virus, four species of virus-specified single-stranded RNA, three species of double-stranded RNA and a multi-stranded RNA species. The mol.
B A, Martin, D C, Burke
openaire   +2 more sources

Hepatitis B virus replication [PDF]

World Journal of Gastroenterology, 2007
Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse transcription of an RNA intermediate, the pregenomic RNA (pgRNA). Despite this kinship to retroviruses, there are fundamental differences beyond the fact that hepadnavirions contain DNA instead of RNA.
Juergen, Beck, Michael, Nassal
openaire   +2 more sources

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

Retrovirology, 2019
Background Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome.
Christine M. Fennessey, Celine Camus, Taina T. Immonen, Carolyn Reid, Frank Maldarelli, Jeffrey D. Lifson, Brandon F. Keele   +6 more
doaj   +1 more source

Murine leukemia virus (MLV) replication monitored with fluorescent proteins

, 2006
Background: Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV) has been described to have potential as cancer therapeutics, however, MLV
Erlwein, Otto, Bittner, Alexandra, Sliva, Katja, Schnierle, Barbara   +3 more
core   +1 more source

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P   +15 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source