Results 81 to 90 of about 753,101 (359)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

T Cell Responses during Acute Respiratory Virus Infection [PDF]

, 2016
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Braciale, Thomas J., Kim, Taeg S., Legge, Kevin L., Sun, Jie   +3 more
core   +1 more source

Hepatitis D Virus Replication [PDF]

Cold Spring Harbor Perspectives in Medicine, 2015
This work reviews specific related aspects of hepatitis delta virus (HDV) reproduction, including virion structure, the RNA genome, the mode of genome replication, the delta antigens, and the assembly of HDV using the envelope proteins of its helper virus, hepatitis B virus (HBV).
openaire   +2 more sources

DNA Virus Replication Compartments [PDF]

Journal of Virology, 2014
ABSTRACTViruses employ a variety of strategies to usurp and control cellular activities through the orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear compartments. Formation of such specialized virus-induced cellular microenvironments, which have been termed viroplasms, virus factories, or virus replication centers ...
Melanie, Schmid, Thomas, Speiseder, Thomas, Dobner, Ramon A, Gonzalez   +3 more
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A universal mammalian vaccine cell line substrate. [PDF]

PLoS ONE, 2017
Using genome-wide small interfering RNA (siRNA) screens for poliovirus, influenza A virus and rotavirus, we validated the top 6 gene hits PV, RV or IAV to search for host genes that when knocked-down (KD) enhanced virus permissiveness and replication ...
Jackelyn Murray, Kyle V Todd, Abhijeet Bakre, Nichole Orr-Burks, Les Jones, Weilin Wu, Ralph A Tripp   +6 more
doaj   +1 more source

Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase [PDF]

, 2015
Chronic infection of the liver by hepatitis C virus (HCV) induces a range of host factors including IFN-stimulated genes such as ISG15. ISG15 functions as an antiviral factor that limits virus replication. Previous studies have suggested that ISG15 could
Bamford, Connor G.G., Boutell, Chris, Domingues, Patricia, McLauchlan, John   +3 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. [PDF]

, 2017
Antiviral innate host defenses against acute viral infections include suppression of host protein synthesis to restrict viral protein production.
Clarissa Santos Rocha, Erica A. Mendes, George R. Thompson, Guochun Jiang, Joseph K. Wong, Lauren A. Hirao, Ruth Ruprecht, Satya Dandekar, Vinayaka R. Prasad, Yuyang Tang   +9 more
core   +5 more sources

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus [PDF]

, 2011
Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication ...
Ali, Binda, Campbell, Campbell, Caplan, Cotsiki, Côté-Martin, DeCaprio, Dilworth, Felici, Feng, Flinn, Hakki, Houben, Jennifer Hein, Lane, Laude, Li, Liang, Linzer, Mannová, Nakamura, Nakamura, Ole V. Gjoerup, Pallas, Patrick S. Moore, Pelkmans, Per H. Basse, Peralta, Pipas, Poupon, Price, Qian, Richardson, Schowalter, Shuda, Shuda, Simon C.W. Richardson, Srinivasan, Sukarieh, Tuna Toptan, Whitman, Wrana, Wurmser, Xi Liu, Yuan Chang   +45 more
core   +2 more sources