Results 131 to 140 of about 494,159 (263)

Structure-function analyses of coiled-coil immune receptors define a hydrophobic module for improving plant virus resistance. [PDF]

J Exp Bot, 2023
Wu X, Zhang X, Wang H, Fang RX, Ye J.
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

The prospects of targeting messenger RNA surveillance factor PELOTA for developing virus resistance in plants. [PDF]

Plant Mol Biol
Majumdar A, Babu YM, Mondal F, Sarkar M, Mazumder P, Pradhan P, Kumar R, Koeda S, Roy A.   +8 more
europepmc   +1 more source

CRISPR/Cas9-guided knockout of eIF4E improves Wheat yellow mosaic virus resistance without yield penalty. [PDF]

Plant Biotechnol J, 2023
Kan J, Cai Y, Cheng C, Chen S, Jiang C, He Z, Yang P.   +6 more
europepmc   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

MutMap-Based Cloning of a Soybean Mosaic Virus Resistance Gene. [PDF]

Plants (Basel)
Wang B, Zhong X, Yu D, Rao D, Niu L, Xun H, Zhu X, Yi L, Qian X, Meng F.   +9 more
europepmc   +1 more source

The key micronutrient copper orchestrates broad-spectrum virus resistance in rice. [PDF]

Sci Adv, 2022
Yao S, Kang J, Guo G, Yang Z, Huang Y, Lan Y, Zhou T, Wang L, Wei C, Xu Z, Li Y.   +10 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Broadening Virus Resistance Through Gene Pyramiding of eIF4E Family Members. [PDF]

Mol Plant Pathol
Suzuki M, Nishikawa M, Yamamoto T, Koinuma H, Keima T, Fujimoto Y, Komatsu K, Hashimoto M, Neriya Y, Maejima K, Namba S, Yamaji Y.   +11 more
europepmc   +1 more source

Two major quantitative trait loci control wheat dwarf virus resistance in four related winter wheat populations. [PDF]

Theor Appl Genet, 2023
Buerstmayr M, Buerstmayr H.
europepmc   +1 more source