Results 151 to 160 of about 494,159 (263)

Mapping and functional characterization of the tomato spotted wilt virus resistance gene SlCHS3 in Solanum lycopersicum. [PDF]

Mol Breed, 2022
Lv J, Deng M, Jiang S, Zhu H, Li Z, Wang Z, Li J, Yang Z, Yue Y, Xu J, Zhao K.   +10 more
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Identification of a QTL region for tomato brown rugose fruit virus resistance in Solanum pimpinellifolium. [PDF]

Theor Appl Genet
Jaiswal N, Zia B, Chanda B, Gilliard A, Shi A, Ling KS.   +5 more
europepmc   +1 more source

Simulating the Commercial Implementation of Gene-Editing for Influenza A Virus Resistance in Pigs: An Economic and Genetic Analysis. [PDF]

Genes (Basel), 2022
Salvesen HA, Byrne TJ, Whitelaw CBA, Hely FS.   +3 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Hepatitis C Virus Resistance-Associated Substitutions in Mexico. [PDF]

Viruses
Jose-Abrego A, Laguna-Meraz S, Roman S, Mariscal-Martinez IM, Panduro A.   +4 more
europepmc   +1 more source

Discovery of SNP Molecular Markers and Candidate Genes Associated with Sacbrood Virus Resistance in Apis cerana cerana Larvae by Whole-Genome Resequencing. [PDF]

Int J Mol Sci, 2023
Hassanyar AK, Nie H, Li Z, Lin Y, Huang J, Woldegiorgis ST, Hussain M, Feng W, Zhang Z, Yu K, Su S.   +10 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A BAC-guided haplotype assembly pipeline increases the resolution of the virus resistance locus CMD2 in cassava. [PDF]

Genome Biol
Cornet L, Zaidi SS, Li J, Ngapout Y, Shakir S, Meunier L, Callot C, Marande W, Hanikenne M, Rombauts S, Van de Peer Y, Vanderschuren H.   +11 more
europepmc   +1 more source

Analysis of R Genes Related to Blackcurrant Reversion Virus Resistance in the Comparative Transcriptome of Ribes nigrum cv. Aldoniai. [PDF]

Plants (Basel), 2022
Juškytė AD, Mažeikienė I, Stanys V.
europepmc   +1 more source