Results 81 to 90 of about 928,472 (311)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Optimized RNA-Silencing Strategies for Rice Ragged Stunt Virus Resistance in Rice

Plants, 2021
Rice ragged stunt virus (RRSV) is one of the most damaging viruses of the rice culture area in south and far-eastern Asia. To date, no genetic resistance has been identified and only expensive and non-environmentally friendly chemical treatments are ...
Severine Lacombe, Martine Bangratz, Hoang Anh Ta, Thanh Duc Nguyen, Pascal Gantet, Christophe Brugidou   +5 more
doaj   +1 more source

Madex Plus and Madex I12 overcome Virus Resistance of Codling Moth [PDF]

, 2008
Over the past three years, codling moth populations with resistance to the Mexican isolate of Cydia pomonella Granulovirus (CpGV) have been found in Germany, France, Italy, Switzerland and the Netherlands.
Zingg, D.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Interactions between vaccinia virus and sensitized macrophages in vitro [PDF]

, 1975
The action of peritoneal exudate cells (PEC) from normal and vaccinia virus infected mice on infectious vaccinia virus particles was investigatedin vitro. PEC from immune mice showed a significantly higher infectivity titre reduction (virus clearance, VC)
A. V. Boand, B. Rager-Zismann, B. Vernon-Roberts, C. A. Mims, C. A. Mims, D. R. Ginder, F. B. Bang, F. R. Avila, G. B. Mackaness, J. A. Roberts, J. G. Stevens, K. T. Brunner, L. F. Reed, M. Nishmi, M. Rabinowitch, M. Rabinowitch, M. S. Hirsch, R. Benda, R. Evans, R. Gallily, R. J. North, R. M. Schultz, R. T. Johnson, S. Ueda, W. A. F. Tompkins, W. Dabrowski   +25 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Genome-Wide Analysis of Soybean Mosaic Virus Reveals Diverse Mechanisms in Parasite-Derived Resistance

Agronomy
Plant viruses cause severe losses in agricultural production. Parasite-derived resistance (PDR) offers a promising avenue for developing disease-resistant varieties independent of resistance genes.
Na Yang, Yanglin Qiu, Yixin Shen, Kai Xu, Jinlong Yin   +4 more
doaj   +1 more source

A contribution to the genetic mapping of resistance to the cotton blue disease using SSR markers [PDF]

, 2009
One of the principal problems in the major cotton producing area of Brazil is the occurrence of diseases, amongst which the Cotton Blue Disease has a major impact.
Barroso, Paulo Augusto Vianna, Cazé, A.L.R., Giband, Marc, Hoffmann, Lucia Vieira, Oliveira, T.S., Pires, Ely, Schuster, Ivan   +6 more
core  

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources