Results 171 to 180 of about 961,541 (308)

Disentangling Temporal Trends of Clade Ib Monkeypox Virus Transmission in Burundi. [PDF]

J Infect Dis
Jin S, Asakura TR, Murayama H, Jung SM, Niyukuri D, Nyandwi J, Nkengurutse L, Kamatari O, Lim JT, Endo A, Dickens BL.   +10 more
europepmc   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Phylodynamic reconstruction of H1N1pdm09 influenza virus transmission in Brazil: a decade of evolutionary dynamics. [PDF]

Emerg Microbes Infect
Brcko IC, de Souza VC, Jeronimo Lima AR, Pereira JS, de Araújo ESA, Valeiros APNV, Palmieri M, Nunes JA, Torres LS, Santos HO, Leite AB, Pereira FM, de Mello ALES, Brandão Nardy V, de Andrade GSM, Astete Gomez MK, Vieira LL, Roll MM, Henrique BVM, Lima Neto LG, Cristina de Oliveira E, Almeida JDPC, da Silva SF, Vasconcelos KR, Adelino TER, Guimaraes NR, Ribeiro Tomé LM, Arend LNVS, da Silva CC, Maia ACS, Mattos CB, Costa GDS, Alcântara LC, Kallás EG, Sampaio SC, Slavov SN, Giovanetti M, Elias MC.   +37 more
europepmc   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Potential vectors associated to Oropouche virus transmission in Cuba, 2024. [PDF]

GigaByte
Sánchez González M, Companioni A, Camacho E, Serrano S, Álvarez M, Rodriguez-Potrony H, Alfonso Y, Liberty B, Varens J, Martínez Y, Menendez Z, Rodríguez Velázquez D, Rivera M, Lugo D, Kouri V, Guzman MG, Gutiérrez-Bugallo G.   +16 more
europepmc   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Modeling Culicoides paraensis distribution and implications for Oropouche virus transmission in Brazil. [PDF]

Parasit Vectors
Lorenz C, de Azevedo TS, Gomes AB, Chiaravalloti-Neto F, Sallum MAM.   +4 more
europepmc   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Ebola virus' hidden target: virus transmission to and infection of skin. [PDF]

J Virol
Richards PT, Fleck AM, Patel R, Fakhimi M, Bohan D, Geoghegan-Barek K, Honko AN, Stolte AE, Plescia CB, Messingham CO, Connell SJ, Crowe TP, Gourronc FA, Carrion R, Griffiths A, Meyerholz DK, Klingelhutz AJ, Davey RA, Messingham KN, Maury W.   +19 more
europepmc   +1 more source