Results 101 to 110 of about 13,089 (196)
Combined approaches to flexible fitting and assessment in virus capsids undergoing conformational change [PDF]
, 2013 Fitting of atomic components into electron cryo-microscopy (cryoEM) density maps is routinely used to understand the structure and function of macromolecular machines.
Shakeel, S. +10 more
core +1 more source
Endosomal ions and serum promote enterovirus uncoating
, 2020 Enterovirusten B ryhmään kuuluva Echovirus 1 on RNA-virus, jonka tiedetään infektoivan soluja ei-happamien endosomien välityksellä ja kerääntyvän neutraaleihin multivesikulaarisiin kappaleisiin.
Haapakoski, Marjo
core
Unraveling the motions behind Enterovirus 71 uncoating
, 2018 Enterovirus 71 can be a severe pathogen in small children and immunocompromised adults. Virus uncoating is a critical step in the infection of the host cell; however, the mechanisms that control this process remain poorly understood.
Ross, Caroline Jane +10 more
core +1 more source
Virus uncoating is required for apoptosis induction in cultured mammalian cells infected with African horse sickness virus [PDF]
, 2015 Infection of cultured mammalian cells with African horse sickness virus (AHSV) is known to induce cell death. To date, the trigger(s) of this response, the apoptotic pathways activated during AHSV infection and the functional consequences of apoptosis ...
Theron, Jacques, Vermaak, Elaine
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Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into Cells
Advances in Virology, 2011 Alphaviruses are small, enveloped viruses, ~70 nm in diameter, containing a single-stranded, positive-sense, RNA genome. Viruses belonging to this genus are predominantly arthropod-borne viruses, known to cause disease in humans.
Jason Yat-Sing Leung +2 more
doaj +1 more source
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
, 2012 Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children that can cause severe central nervous system disease and death. No vaccine or antiviral therapy is available.
Zihe Rao +39 more
core +1 more source
The effect of capsid mutations on HIV-1 uncoating
, 2007 Efficient uncoating requires not only an optimal cellular environment, but also some intrinsic properties of the viral capsid protein itself. Using an in vitro uncoating model, we demonstrated that substitution of each serine residue with alanine at the ...
Lauhakirti, Darat +2 more
core +1 more source
Probing recombinant AAV capsid integrity and genome release after thermal stress by mass photometry
Molecular Therapy: Methods & Clinical DevelopmentAdeno-associated viruses (AAVs) are gaining traction as delivery vehicles for gene therapy although the molecular understanding of AAV-transgene release is still limited.
Eduard H.T.M. Ebberink +6 more
doaj +1 more source
Studying Factors that Contribute to Uncoating of Enteroviruses
, 2020 Enteroviruses are small, non-enveloped viruses with a positive sense single stranded RNA genome. They cause different diseases in humans, usually with symptoms of common cold, but also more severe acute and chronic infections such as encephalitis and ...
Ruokolainen, Visa
core +1 more source
, 2015 The role of cellular Rab GTPases that govern traffic between different endosome populations was analysed on foot-and-mouth disease virus (FMDV) infection. Changes of viral receptor specificity did not alter Rab5 requirement for infection.
Martín-Acebes, M. A. +6 more
core +1 more source