Results 91 to 100 of about 13,089 (196)

Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects

Retrovirology, 2012
Background Disassembly of the viral capsid following penetration into the cytoplasm, or uncoating, is a poorly understood stage of retrovirus infection. Based on previous studies of HIV-1 CA mutants exhibiting altered capsid stability, we concluded that ...
Yang Ruifeng, Shi Jiong, Byeon In-Ja L, Ahn Jinwoo, Sheehan Jonathan H, Meiler Jens, Gronenborn Angela M, Aiken Christopher   +7 more
doaj   +1 more source

Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding, Wenhao Li, Ling Mei, Suling Luo, Jing Tao, Chongxiu Shi, Hongping Yang, Wei Feng, Yungchang Chen, Yu Chen, Jong Seung Kim, Xue Shen   +11 more
wiley   +1 more source

HIV-1 Virus Interactions With Host Proteins: Interaction of the N-terminal Domain of the HIV-1 Capsid Protein With Human Calmodulin

Natural Product Communications, 2019
The human immunodeficiency virus (HIV-1 virus) exploits several host factors for assembly, infection, and replication within the infected cells. In this work, we describe the evidence for an interaction of the N-terminal domain of the HIV-1 capsid ...
Ywh-Min Tzou, Ronald Shin, N. Rama Krishna   +2 more
doaj   +1 more source

In situ analysis of human immunodeficiency virus uncoating.

, 2008
In situ analysis of human immunodeficiency virus ...
Omar. Perez (7974347)
core  

Ubiquitin in Influenza Virus Entry and Innate Immunity

Viruses, 2016
Viruses are obligatory cellular parasites. Their mission is to enter a host cell, to transfer the viral genome, and to replicate progeny whilst diverting cellular immunity.
Alina Rudnicka, Yohei Yamauchi
doaj   +1 more source

Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site

Viruses, 2017
African swine fever virus (ASFV) infection causes endosomal reorganization. Here, we show that the virus causes endosomal congregation close to the nucleus as the infection progresses, which is necessary to build a compact viral replication organelle ...
Miguel Ángel Cuesta-Geijo, Lucía Barrado-Gil, Inmaculada Galindo, Raquel Muñoz-Moreno, Covadonga Alonso   +4 more
doaj   +1 more source

Multiple Mechanisms for the Inhibition of Entry and Uncoating of Superinfecting Semliki Forest Virus

, 1997
Recombinant Semliki Forest viruses (SFV) that express one or none of the viral structural proteins were used to infect cells and to analyze the fate of incoming superinfecting wild-type viruses.
Garoff, Henrik, Suomalainen, Maarit, Varadarajan, Sujata, Singh, Ila R., Helenius, Ari   +4 more
core   +1 more source

HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain

mBio, 2018
Once HIV-1 enters a cell, the viral core is uncoated by a poorly understood mechanism and the HIV-1 genomic RNA is reverse transcribed into DNA. Host cell factors are essential for these processes, although very few reverse transcription complex binding ...
Daniel J. Rawle, Dongsheng Li, Joakim E. Swedberg, Lu Wang, Dinesh C. Soares, David Harrich   +5 more
doaj   +1 more source

Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats

, 2008
Background: Vectors based on adeno-associated virus-8 (AAV8) have shown efficiency and efficacy for liver-directed gene therapy protocols following intravascular injection, particularly in relation to haemophilia gene therapy. AAV8 has also been proposed
Amit Nathwani, Baker, AH, Lorraine M Work, Tracey Graham, McIntosh, JB, Jenny McIntosh, Nathwani, A, Work, LM, Graham, T, McIntosh, J, Andrew H Baker   +10 more
core   +1 more source

Model for ASFV internalization and uncoating.

, 2016
ASFV enters swine macrophages by clathrin-mediated endocytosis (left) and constitutive macropinocytosis (right). After the uptake, incoming particles are transported from early endosomes or macropinosomes to late endosomes, where they undergo the ...
Germán Andrés (2626936), Milagros Guerra (2626933), Bruno Hernáez (122886), María L. Salas (831738)   +3 more
core   +1 more source