Results 211 to 220 of about 1,547,632 (301)

A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus. [PDF]

Virulence
Xiang Z, Li G, Wang J, Ma C, Ge X, Gao P, Zhou Q, Guo X, Zhou L, Han J, Zhang Y, Yang H.   +11 more
europepmc   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

The NS4B A119T mutation of dengue virus 2 confers adaptation to mammalian cells and increased pathogenicity in AG129 mice. [PDF]

J Gen Virol
Tabata K, Itakura Y, Uemura K, Mulavu M, Yamashita M, Matsushita T, Kusakabe S, Toba S, Sasaki M, Saito S, Gonzalez G, Hall WW, Sawa H, Sato A, Orba Y.   +14 more
europepmc   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Integrated Transcriptome-Translatome Analysis Reveals Translational Buffering in the Liver of Chickens Infected with Fowl Adenovirus Serotype 4 Strain GXYL-03, a Strain with Reduced Virulence. [PDF]

Microorganisms
Wei Y, Fan Q, Xie Z, Li X, Wang S, Yang B, Zhang Y, Wan L, Wu A, Ren H, Chen Z, Xie L, Li M, Hu T, Luo S.   +14 more
europepmc   +1 more source

Mutations in the E2 Glycoprotein and the 3' Untranslated Region Enhance Chikungunya Virus Virulence in Mice. [PDF]

J Virol, 2017
Hawman DW, Carpentier KS, Fox JM, May NA, Sanders W, Montgomery SA, Moorman NJ, Diamond MS, Morrison TE.   +8 more
europepmc   +1 more source

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

Long-term exposure to laboratory conditions: can adaptation reshape the biology of pathogens? [PDF]

Front Plant Sci
Singh S, Dixelius C.
europepmc   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Comparative Phenotypic Characterization of Five CRISPR/Cas9-Generated Gene-Disrupted Mutants of Pseudorabies Virus JM Strain. [PDF]

Vet Sci
Han L, Wang S, Zhang Z, Weng C.
europepmc   +1 more source