Results 101 to 110 of about 1,996,758 (380)
Molecular Oncology, EarlyView.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source
Acta Biochimica PolonicaThe aim of the study was to determine the level of anti-hemagglutinin antibodies in the serum of patients during the 2021/2022 epidemic season in Poland.
Katarzyna Kondratiuk +5 more
doaj +1 more source
Communications Biology, 2022 Human alveolar epithelial lentivirus immortalized cells are very permissive for human coronaviruses and influenza A viruses, provided a suitable model for such infections of the lower respiratory tract as shown by reduced propagation of the SARS-CoV-2 ...
Christin Mache +9 more
doaj +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Health Science Reports, 2021 Background and Aims In the United States, respiratory infections due to respiratory syncytial virus (RSV) cause an estimated 57 000 hospitalizations annually among children aged
Mila M. Prill +3 more
doaj +1 more source
Towards Metamorphic Virus Recognition Using Eigenviruses [PDF]
arXiv, 2012 Metamorphic viruses are considered the most dangerous of all computer viruses. Unlike other computer viruses that can be detected statically using static signature technique or dynamically using emulators, metamorphic viruses change their code to avoid such detection techniques.
arxiv
Multiscale statistical physics of the Human-SARS-CoV-2 interactome [PDF]
arXiv, 2020 Protein-protein interaction (PPI) networks have been used to investigate the influence of SARS-CoV-2 viral proteins on the function of human cells, laying out a deeper understanding of COVID--19 and providing ground for drug repurposing strategies. However, our knowledge of (dis)similarities between this one and other viral agents is still very limited.
arxiv
Viruses, 2010 As obligatory intracellular pathogens, viruses exploit various cellular molecules and structures, such as cellular membranes, for their propagation. Enveloped viruses acquire lipid membranes as their outer coat through interactions with cellular membranes during morphogenesis within, and egress from, infected cells.
openaire +4 more sources
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
The Spread of Viruses and Bugs in Self Organizing Networks [PDF]
arXiv, 2011 We review recent progress made in analyzing the spread of viruses and bugs in the internet. We describe how the use of a model that takes into account the complex inhomogeneity of the internet and its self organizing characteristics can lead to a better understanding of the persistence of some viruses compared to others.
arxiv