Results 101 to 110 of about 3,207,629 (358)

Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs [PDF]

, 2018
Alejandro Larios Mora, Laurent Detalle, Jack M. Gallup, Albert Van Geelen, Thomas Stöhr, Linde Duprez, Mark R. Ackermann   +6 more
openalex   +1 more source

Antiviral Potential of Azelastine against Major Respiratory Viruses [PDF]

, 2023
Katrin Fischhuber, Zoltán Bánki, Janine Kimpel, Natalie Kragl, Annika Rössler, Annika Bolze, Brigitte Muellauer, Joachim Angerer, Gábor Nagy, Eszter Nagy, Valéria Szijártó   +10 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b in wild rats in Egypt during 2023

Emerging Microbes and Infections
We detected highly pathogenic avian influenza A(H5N1) virus in wild rats collected from a rural area in Giza, Egypt, near poultry farms, markets, and backyard flocks.
Omnia Kutkat, Mokhtar Gomaa, Yassmin Moatasim, Ahmed El Taweel, Mina Nabil Kamel, Mohamed El Sayes, Mohamed GabAllah, Ahmed Kandeil, Pamela P. McKenzie, Richard J. Webby, Ghazi Kayali, Mohamed Ahmed Ali, Rabeh El-Shesheny   +12 more
doaj   +1 more source

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl‐transferase [PDF]

, 2007
Marcos de la Peña, O.J.P. Kyrieleis, S. Cusack   +2 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Circulating Avian Influenza Viruses Closely Related to the 1918 Virus Have Pandemic Potential [PDF]

, 2014
Tokiko Watanabe, Gongxun Zhong, Colin A. Russell, Noriko Nakajima, Masato Hatta, Anthony Hanson, Ryan McBride, David F. Burke, Kenta Takahashi, Satoshi Fukuyama, Yuriko Tomita, Eileen A. Maher, Shinji Watanabe, Masaki Imai, Gabriele Neumann, Hideki Hasegawa, James C. Paulson, Derek J. Smith, Yoshihiro Kawaoka   +18 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Optimized production of a truncated form of the recombinant neuraminidase of influenza virus in Escherichia coli as host with suitable functional activity

Microbial Cell Factories
Background To discover effective drugs for treating Influenza (a disease with high annual mortality), large amounts of recombinant neuraminidase (NA) with suitable catalytic activity are needed. However, the functional activity of the full-length form of
Fatemeh Sadat Shariati, Fatemeh Fotouhi, Behrokh Farahmand, Zahra Barghi, Kayhan Azadmanesh   +4 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source