Results 51 to 60 of about 3,729,339 (351)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Giant viruses [PDF]

Current Biology, 2020
Chantal Abergel and Jean-Michel Claverie introduce giant viruses.
Abergel, Chantal, Claverie, Jean-Michel
openaire   +3 more sources

Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]

, 2014
Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent, Anderson, Bao, Bowman, Brown, Centers for Disease Control and Prevention, Core Team R, D. F. Burke, Darriba, De Jong, E. Skepner, Edgar, Feng, Fouchier, Garten, Gauger, Harmon, Hinshaw, Houser, Karasin, Kawaoka, Khurana, Kitikoon, Koel, Lewis, Lindstrom, Lorusso, Loving, Maddison, Miller, Montalvao, Myers, N. S. Lewis, Nelson, Nelson, Nfon, Olsen, P. Kitikoon, Paradis, Pena, Polewicz, PyMOL, Röhm, Salmon, Shinde, Skowronski, Smith, Smith, Stamatakis, T. K. Anderson, Tong, Tong, Vincent, Vincent, Vincent, Vincent, Webby, Webby, Ye   +58 more
core   +1 more source

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Science, 2009
Generation of Swine Flu As the newly emerged influenza virus starts its journey to infect the world's human population, the genetic secrets of the 2009 outbreak of swine influenza A(H1N1) are being revealed.
R. Garten, C. Davis, C. Russell, B. Shu, S. Lindstrom, A. Balish, W. Sessions, Xiyan Xu, E. Skepner, V. Deyde, M. Okomo-Adhiambo, L. Gubareva, J. Barnes, Catherine Bender Smith, S. Emery, M. Hillman, P. Rivailler, James A. Smagala, M. de Graaf, D. Burke, R. Fouchier, C. Pappas, C. Alpuche-Aranda, H. Lopez-Gatell, Hiram Olivera, Irma López, Christopher A. Myers, D. Faix, P. Blair, Cindy Yu, Kimberly M Keene, P. D. Dotson, D. Boxrud, A. Sambol, S. Abid, K. St. George, T. Bannerman, A. Moore, D. J. Stringer, Patricia Blevins, Gail J. Demmler-Harrison, M. Ginsberg, P. Kriner, S. Waterman, S. Smole, H. Guevara, E. Belongia, P. A. Clark, S. Beatrice, R. Donis, J. Katz, L. Finelli, C. Bridges, M. Shaw, D. Jernigan, T. Uyeki, Derek J. Smith, A. Klimov, N. Cox   +58 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Viruses and autoimmunity

Autoimmunity, 2005
Viruses have been suspected as causes and contributors of human autoimmune diseases (AID), although direct evidence for the association is lacking. However, several animal models provide strong evidence that viruses can induce AIDs as well as act to accelerate and exacerbate lesions in situations where self-tolerance is broken.
Shilpa Deshpande Kaistha, Bumseok Kim, Barry T. Rouse   +2 more
openaire   +4 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Viruses in the Nucleus

Cold Spring Harbor Perspectives in Biology, 2021
Viral infection is intrinsically linked to the capacity of the virus to generate progeny. Many DNA and some RNA viruses need to access the nuclear machinery and therefore transverse the nuclear envelope barrier through the nuclear pore complex. Viral genomes then become chromatinized either in their episomal form or upon integration into the host ...
Lucic, B, de Castro, IJ, Lusic, M
openaire   +5 more sources

Transmission of viruses via our microbiomes. [PDF]

, 2016
BackgroundBacteria inhabiting the human body have important roles in a number of physiological processes and are known to be shared amongst genetically-related individuals.
Abeles, Shira R, Chan, Ivan C, Gao, Jonathan, Ghose, Chandrabali, Jones, Marcus B, Ly, Melissa, Pride, David T, Santiago-Rodriguez, Tasha M   +7 more
core   +1 more source

Nosocomial Transmission of Emerging Viruses via Aerosol-Generating Medical Procedures

Viruses, 2019
Recent nosocomial transmission events of emerging and re-emerging viruses, including Ebola virus, Middle East respiratory syndrome coronavirus, Nipah virus, and Crimean–Congo hemorrhagic fever orthonairovirus, have highlighted the risk of nosocomial ...
S. Judson, V. Munster
semanticscholar   +1 more source