Results 91 to 100 of about 216,511 (353)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Pathophysiology and Pathogenesis of Visceral Fat Obesity [PDF]

Obesity Research, 1995
AbstractBased on the analysis of fat distribution by computed tomography (CT) scans, the classification scheme for obesity should include visceral fat obesity in which fat accumulation is predominant in the intra‐abdominal cavity. Obese subjects with visceral fat accumulation more frequently demonstrate impairment of glucose and lipid metabolism than ...
Y, Matsuzawa, I, Shimomura, T, Nakamura, Y, Keno, K, Kotani, K, Tokunaga   +5 more
openaire   +2 more sources

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
core   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Obese patients with a binge eating disorder have an unfavorable metabolic and inflammatory profile [PDF]

, 2015
To evaluate whether obese patients with a binge eating disorder (BED) have an altered metabolic and inflammatory profile related to their eating behaviors compared with non-BED obese.A total of 115 White obese patients consecutively recruited underwent ...
Aloi, M, Arturi, F, Caroleo, M, De Fazio, P, Rania, M, Ruffo, M, Segura-Garcia, C, Sesti, G, Succurro, E   +8 more
core   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Sonographic Prediction of Body Fat Volume (Subcutaneous and Visceral Fat) in Cardiovascular Patients [PDF]

Journal of Tehran University Heart Center, 2010
Background: Inappropriate body composition represents impaired energy and nutrient intake and can be a risk factor for many diseases, especially for cardiovascular disease.
Maryam Soleymanzadeh, Mohammad Reza Eshraghian, Shapour Shirani, Mir Hatef Shojaei   +3 more
doaj   +2 more sources

Direct Measurements of Abdominal Visceral Fat and Cognitive Impairment in Late Life: Findings From an Autopsy Study

Frontiers in Aging Neuroscience, 2019
Background: The relationship between cognitive impairment and abdominal visceral is controversial. Moreover, all studies so far used imaging studies to evaluate visceral fat and this association has not been described yet using autopsy material, which ...
Aline Nishizawa, Anderson Cuelho, Daniela S. de Farias-Itao, Fernanda M. Campos, Renata E. P. Leite, Renata E. L. Ferretti-Rebustini, Lea T. Grinberg, Ricardo Nitrini, Wilson Jacob-Filho, Carlos A. Pasqualucci, Claudia K. Suemoto   +10 more
doaj   +1 more source

Compartmental fat distribution in the abdomen of dogs relative to overall body fat composition

BMC Veterinary Research, 2020
Background Adipose tissue may have different metabolic and endocrine functions depending on the region of the body in which it is located. While visceral or intra-abdominal fat has been found to contribute to leptin concentrations, insulin resistance and
R. B. S. Turner, D. Tyrrell, G. Hepworth, F. R. Dunshea, C. S. Mansfield   +4 more
doaj   +1 more source

Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: an ultrasonography study [PDF]

, 2015
AIMS:Glucagon-like peptide 1 receptor agonists (GLP-1 RA) induce weight loss and reduction in adipose tissue, but the effects of GLP-1 RA on the distribution of fat deposits have been poorly investigated. METHODS: In 25 patients with type 2 diabetes (16
Carnevale, Vincenzo, Dagostino, Mariangela Pia, Fallarino, Mara, Filardi, Tiziana, Lenzi, Andrea, Mandosi, Elisabetta, Morano, Susanna, Nieddu, Luciano, Romagnoli, Elisabetta, Turinese, Irene   +9 more
core   +1 more source