Results 131 to 140 of about 309,484 (272)

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

A-Type KV Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction [PDF]

, 2018
A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability that have been mainly characterized in the central nervous system. By contrast, there is a paucity of knowledge about the molecular physiology of these Kv channels
Covarrubias, Manuel, Muqeem, Tanziyah, Ritter, David M., Zemel, Benjamin M.   +3 more
core   +1 more source

Visceral hypersensitivity is together with psychological distress and female gender associated with severity of IBS‐like symptoms in quiescent ulcerative colitis

Neurogastroenterology and Motility, 2020
A subset of ulcerative colitis (UC) patients in remission demonstrate IBS‐like symptoms. Visceral hypersensitivity is a key pathophysiological mechanism in IBS, but its relevance to IBS‐like symptoms in inactive UC remains unclear.
G. Mavroudis, H. Strid, Börje Jonefjäll, M. Simrén   +3 more
semanticscholar   +1 more source

Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High‐Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader‐Blinded Study

Neurogastroenterology &Motility, EarlyView.
Our study showed that, in healthy controls, acute administration of linaclotide increased the total number of long‐distance propagating and the pre‐prandial pancolonic pressurizations. Further studies need to address whether the observed effects are directly or indirectly mediated by the mechanism of action of this useful medication to treat chronic ...
Christian Lambiase, Giuseppe Pagliaro, Silvia Cocca, Eveline Deloose, Ingrid Demedts, Riccardo Morganti, Jan Tack, Maura Corsetti   +7 more
wiley   +1 more source

INFLAMMATION IN IRRITABLE BOWEL SYNDROME: MYTH OR NEW TREATMENT TARGET? [PDF]

, 2016
Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS,
Amvrosiadis,G, CAPPELLO, Francesco, LO MONTE, Attilio Ignazio, Morreale,GC, Pompei,G, Raimondo,D, Rizzo,G, Rossi,F, SINAGRA, Emanuele, TOMASELLO, Giovanni   +9 more
core   +1 more source

Haplotype‐Resolved Genome Assembly and Population Genomics Reveal Evolutionary History and Agronomic Traits of Mulberry

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mulberry is a representative economic tree species valued for both poverty alleviation and medicinal use. To advance the understanding of mulberry genomics and demography, we assembled high‐quality haploid genomes of two widely cultivated mulberry varieties NS14 and QS1, and analysed 376 accessions from 12 countries, including 39 ancient trees
Zhifeng Wang, Peigang Liu, Chengzhi Jiao, Yazhou Zhang, Zilong Xu, Tianbao Lin, Yan Zhu, Xin Jing, Yuan Huang, Nan Chao, Mengjie Zhao, Yan Liu, Huizi Liu, Bo Sun, Fen Zhang, Quanzi Li, Zhiqiang Lv, Xuepeng Sun, Ying‐Chung Jimmy Lin, Jia Wei   +19 more
wiley   +1 more source

Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats

Brazilian Journal of Medical and Biological Research, 2012
Visceral hypersensitivity plays an important role in motor and sensory abnormalities associated with irritable bowel syndrome, but the underlying mechanisms are not fully understood.
Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xuan   +4 more
doaj   +2 more sources

Dissecting the Cell‐Type‐Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar‐Dependent Involvement of Brassinosteroid Signalling

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses drive widespread crop epidemics, yet the host plant responses across different cell types, particularly how these responses are influenced by cultivars with varying genetic backgrounds, including the presence of resistance (R) genes, remain poorly understood. Using tomato brown rugose fruit virus (ToBRFV) and two tomato cultivars,
Yuhong Zhang, Shan Bu, Yuxin Nie, Luyou Wang, Jiayi Liu, Junchen Xu, Jiejun Peng, Fei Yan, Jian Wu   +8 more
wiley   +1 more source

P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

PLoS ONE, 2015
ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.
Annemie Deiteren, Laura van der Linden, Anouk de Wit, Hannah Ceuleers, Roeland Buckinx, Jean-Pierre Timmermans, Tom G Moreels, Paul A Pelckmans, Joris G De Man, Benedicte Y De Winter   +9 more
doaj   +1 more source

A pilot study of temsirolimus and body composition. [PDF]

, 2013
PurposeBody weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss ...
Janku, Filip, Kurzrock, Razelle, Naing, Aung, Parsons, Henrique A, Tsimberidou, Apostolia M, Veasey-Rodrigues, Heloisa, Wheler, Jennifer J   +6 more
core   +2 more sources