Results 161 to 170 of about 309,484 (272)

Gut microbiota and central nervous system's direct bidirectional regulation: The mechanisms of the gut–brain axis in irritable bowel syndrome

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Gut microbiota directly modulates central nervous system activity via vagal, sympathetic and sensory neural circuits. Brainstem nuclei integrate microbial signals to regulate gut motility, secretion and visceral sensitivity. DRG neurons and stress‐responsive pathways link microbial cues to host defence and epithelial homeostasis. Dysregulated gut–brain
Jinxia Zhai, Yingjie Li, Jiameng Liu, Cong Dai   +3 more
wiley   +1 more source

Cumulative Effects of Psychologic Distress, Visceral Hypersensitivity, and Abnormal Transit on Patient-reported Outcomes in Irritable Bowel Syndrome.

Gastroenterology, 2019
BACKGROUND & AIMS Little is known about the link between pathophysiologic factors and symptoms of irritable bowel syndrome (IBS), or whether these factors have cumulative effects on patient-reported outcomes (PROs).
M. Simrén, H. Törnblom, O. Palsson, L. Van Oudenhove, W. Whitehead, J. Tack   +5 more
semanticscholar   +1 more source

Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Whey proteins possess antimicrobial and prebiotic properties that modulate gut microbiota by promoting beneficial bacteria like Bifidobacterium while suppressing pathogens. This modulation enhances short‐chain fatty acid production and strengthens intestinal barrier integrity, potentially alleviating dysbiosis‐related conditions such as colitis and ...
Tolulope Joshua Ashaolu, Chi‐Ching Lee, Ozgur Tarhan, Ali Rashidinejad, Seid Mahdi Jafari   +4 more
wiley   +1 more source

The Association Between Irritable Bowel Syndrome and Generalized Anxiety Disorder and Influencing Factors: A Mediation Mendelian Randomization Study

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Based on Mendelian randomization analysis, this study established a significant causal effect of irritable bowel syndrome (IBS) on increasing generalized anxiety disorder (GAD) risk (odds ratio = 1.328; p < 0.001) and identified dozens of gut microbial taxa, plasma metabolites, inflammatory factors, and immune cell characteristics with potential causal
Weili Yang, Yongxi Wang, Shasha Wang, Hongbing Zhai, Jun Che, Xin Wang, Yafeng Yang, Zebo Jia   +7 more
wiley   +1 more source

Recovery from symptoms using an extensively hydrolyzed formula with synbiotic in infants with presumed cow's milk allergy

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 605-614, February 2026.
Abstract Objective Extensively hydrolyzed formulas (eHF) are the first‐line approach for cow's milk protein allergy (CMPA). This study evaluated the effects of eHF with synbiotic eHF (SeHF) on the general condition and symptoms of presumed CMPA infants during the initial 4‐week exclusion diet period.
Anaïs Lemoine, Florence Villard‐Truc, Imene Ait Mohamed Amar, François Payot   +3 more
wiley   +1 more source

An interorgan neuroimmune circuit promotes visceral hypersensitivity

Abstract Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ systems has remained a mystery.
Brian Kim, Zhen Wang, Xia Meng, Zili Xie, Chia Chun Hor, wenwen zhang, Xu Li, Keaton Song, Kelsey Auyeung, Hisato Iriki, Rintaro Shibuya, Wen Zhang, Jack Major, Lydia Zamidar, Daniel Yassky, Olivia Seker, Joshua Wollam, Christiane Villescaz, Alan Vest, Swetha Sriniva, Michelle Solomon, Rui Chang, Shruti Naik, Masato Kubo, Veena Viswanath, Shawn Xu, Xinzhong Dong, David Artis, Bo Duan, Hongzhen Hu   +29 more
openaire   +2 more sources

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

The long road to diagnosis, from gastroesophageal reflux disease, through Barrett's esophagus, to visceral hypersensitivity: a case report

Journal of Education, Health and Sport
Background: Visceral hypersensitivity syndrome is a condition involving excessive perception of mechanical stimuli in the intestines. In patients suffering from this disorder, physiological bowel function causes pain and discomfort.
Małgorzata Wirkijowska, Jolanta Mędyk, Yauheniya Patarocha, Michał Rogulski, Aleksandra Ślusarska, Paulina Błasiak, Patryk Mikołajec, Ruslan Huk, Barbara Bilecka, Jakub Wirkijowski   +9 more
doaj   +1 more source

A Roadmap for Advancing Women's Health in Disorders of the Gut‐Brain Interaction

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Disorders of the Gut‐Brain Interaction (DGBI) are highly prevalent conditions that all gastroenterologists encounter in clinical practice. Differences between men and women in the prevalence and symptom burden of DGBI have been well documented in numerous epidemiological and observational studies.
Madison R. Heath, Yuying Luo
wiley   +1 more source

Environmental enrichment reverses stress-induced changes in the brain-gut axis to ameliorate chronic visceral and somatic hypersensitivity

Neurobiology of Stress
Introduction: Behavioral therapies, including cognitive behavioral therapy, hypnotherapy and stress management activities, have emerged as effective treatments for irritable bowel syndrome (IBS), a female predominant disorder of the brain-gut axis.
A. Orock, A.C. Johnson, E. Mohammadi, B. Greenwood-Van Meerveld   +3 more
doaj   +1 more source