Results 221 to 230 of about 35,094 (254)

Study of visceral hypersensitivity in irritable bowel syndrome

Chinese Journal of Digestive Diseases, 2004
OBJECTIVE:  Visceral hypersensitivity is highly prevalent in most functional bowel disorders, such as irritable bowel syndrome (IBS), and activation of intestinal mast cells (MC) may play a role because they have been found in close proximity to gastrointestinal mucosal sensory nerve terminals containing neuropeptides and a bi‐directional pathway ...
Wen Zhu, Dong, Duo Wu, Zou, Zhao Shen, Li, Xiao Ping, Zou, Ai Yong, Zhu, Guo Ming, Xu, Ning, Yin, Yan Fang, Gong, Zhen Xing, Sun, Xiao Hua, Man   +9 more
openaire   +2 more sources

Visceral Pain and Hypersensitivity Disorders

2019
Visceral pain and hypersensitivity disorders are common but poorly understood, and their specific treatment is even more limited than for somatic disorders. Visceral hypersensitivity is mediated by small sensory fibers, the Aδ and C afferents, and results from their lowered activation thresholds, change in phenotype, or altered regional density ...
Rosario Privitera, Praveen Anand
openaire   +1 more source

Anorectal Function and Visceral Hypersensitivity in Celiac Disease

Journal of Clinical Gastroenterology, 2010
To evaluate anorectal function and rectal sensitivity thresholds in patients with celiac disease (CD).In 25 unselected patients with CD (16 female, 9 male; mean age 45, range 24 to 75 y) and 20 controls (12 female, 8 male; mean age 41, range 20 to 65 y) anorectal manometry and rectal balloon distension test were conducted using a 4 lumen water perfused
Agata, Mulak, Ewa, Waszczuk, Leszek, Paradowski   +2 more
openaire   +2 more sources

Early-life stress induces visceral hypersensitivity in mice

Neuroscience Letters, 2012
Early-life stress is a risk factor for irritable bowel syndrome (IBS), a common and debilitating functional gastrointestinal disorder that is often co-morbid with stress-related psychiatric disorders. In the rat, maternal separation (MS) stress has been shown to induce visceral hypersensitivity in adulthood and thus has become a useful model of IBS ...
Moloney, Rachel D., O'Leary, Olivia F., Felice, Daniela, Bettler, Bernhard, Dinan, Timothy G., Cryan, John F.   +5 more
openaire   +3 more sources

Irritable pouch syndrome is characterized by visceral hypersensitivity

Inflammatory Bowel Diseases, 2011
Irritable pouch syndrome (IPS) is a functional disorder in patients with ileal pouch-anal anastomosis (IPAA), which presents with symptoms in the absence of structural abnormalities of the pouch. Thus, it resembles other functional disorders, such as irritable bowel syndrome characterized by visceral hypersensitivity in the presence of normal rectal ...
Bo, Shen, Claudia, Sanmiguel, Ana E, Bennett, Lei, Lian, Brett, Larive, Feza H, Remzi, Victor W, Fazio, Edy E, Soffer   +7 more
openaire   +2 more sources

P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity

Gut, 2008
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterised by abdominal pain and bloating in association with altered bowel movements. Its pathogenesis and the underlying molecular mechanisms of visceral hyperalgesia remain elusive. Recent studies of somatic and other visceral pain models suggest a role for purinergic signalling
G-Y, Xu, M, Shenoy, J H, Winston, S, Mittal, P J, Pasricha   +4 more
openaire   +2 more sources

Visceral Hypersensitivity in Functional Dyspepsia (FD): Therapeutic Approaches to FD Based on Suppression of Visceral Hypersensitivity

2018
Visceral hypersensitivity is an important mechanism in the development of functional gastrointestinal disorders (FGID), including irritable bowel syndrome (IBS), noncardiac disorder, and functional dyspepsia (FD). In pathophysiology of FD, visceral hypersensitivity in gastric distension is a main mechanism in addition to gastric motor dysfunction ...
Yasuhito Uezono, Kanako Miyano
openaire   +1 more source

Visceral hypersensitivity and impaired accommodation in refractory diabetic gastroparesis

Neurogastroenterology & Motility, 2008
Abstract  The pathophysiology of persistent gastrointestinal (GI) symptoms in patients with diabetic gastroparesis is poorly understood. Our aim was to evaluate gastric sensation and accommodation to a meal in patients with diabetic gastroparesis and refractory symptoms.
A, Kumar, A, Attaluri, S, Hashmi, K S, Schulze, S S C, Rao   +4 more
openaire   +2 more sources

Review article: visceral hypersensitivity.

Alimentary pharmacology & therapeutics, 2003
Visceral hypersensitivity is highly prevalent in all functional bowel disorders. Most also demonstrate wider patterns of somatic referral of intestinal pain or discomfort. This hypersensitivity may explain the symptoms as the sensitive gut can be more easily provoked by normal or abnormal motor events in the gut.
openaire   +1 more source

Parental Care, Mast Cells and Visceral Hypersensitivity

Journal of Pediatric Gastroenterology and Nutrition, 2005
van den Wijngaard, René, Welting, Olaf, de Jonge, Wouter, Boeckxstaens, Guy   +3 more
openaire   +2 more sources