Results 51 to 60 of about 226,280 (311)

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis

Innate Immunity, 2021
Genetic variations in the host TLRs genes play an important role in susceptibility and/or resistance to visceral leishmaniasis by altering the host-pathogen interaction.
Abhishek Mandal, Manish Kumar, Ashish Kumar, Abhik Sen, Pradeep Das, Sushmita Das   +5 more
doaj   +1 more source

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, EarlyView.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, EarlyView.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

PLoS Neglected Tropical Diseases, 2017
Background Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin condition that often occurs in ...
Mohamed Osman, Anoop Mistry, A. Keding, R. Gabe, Elizabeth Cook, Sarah Forrester, R. Wiggins, S. Di Marco, S. Colloca, L. Siani, R. Cortese, Deborah F. Smith, T. Aebischer, P. Kaye, C. Lacey   +14 more
semanticscholar   +1 more source

Domestic dog ownership in Iran is a risk factor for human infection with Leishmania infantum. [PDF]

, 2002
One explanation proposed for the widespread failure to control zoonotic visceral leishmaniasis by culling infected domestic dogs is that wild canids or humans play significant roles in transmission.
Davies, Clive R, Edrissian, Gholan H, Gavgani, A Samad Mazloumi, Mohebali, Mehdi, Mohite, Hassan   +4 more
core   +1 more source

Treatment of Visceral Leishmaniasis

Archives of Pediatrics & Adolescent Medicine, 1992
Sir .—Mahieu and Van Acker 1 reported a case of visceral leishmaniasis (kalaazar) in the November 1991 issue of AJDC . Several case reports were included in the references, but only a few were from Mediterranean countries in which the disease is more prevalent, as mentioned by the authors. I would like to bring our experience with this disease into the
openaire   +3 more sources

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, EarlyView.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source

[Visceral leishmaniasis].

Vnitrni lekarstvi, 2013
Leishmaniasis is a disease caused by protozoan parasite of genus Leishmania which is transmitted through bites ofinfected sand flies. It has been reported that Polymerase chain reaction (PCR) is more sensitive and specific test for the diagnosis ofvisceral leishmaniasis than bone marrow examination. This recent study is a renewed effort to validate the
MUHAMMAD USMAN, FAYYAZ HUSSAIN, MUHAMMAD KASHIF BAIG   +2 more
openaire   +4 more sources

Incidence of Trypanosoma cruzi infection in two Guatemalan communities.

, 2004
The prevalence of human infection by Trypanosoma cruzi was assessed using an enzyme-linked immunosorbent assay (ELISA) in a serological survey in 1998 of 2 rural communities (SMH and PS) in Guatemala.
Davies, C, Lines, J, Monroy, C, Paz-Bailey, G, Rodas, A, Rosales, R, Tabaru, R   +6 more
core   +1 more source