Results 51 to 60 of about 666,764 (304)

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Identifying gut microbiota Faecalibacterium as a potential biomarker for distinguishing visceral or subcutaneous obese population

Frontiers in Microbiology
BackgroundObesity is a global health issue, with sharply increasing rates due to excessive food intake and reduced physical activity, leading to an increased risk of various chronic diseases, such as type 2 diabetes and cardiovascular diseases.
Yi Li, Yi Li, Senlin Wang, Senlin Wang, Senlin Wang, Senlin Wang, Senlin Wang, Song Zhang, Ergan Li, Meifang Liang, Youqin Li, Youqin Li, Youqin Li, Youqin Li, Anke Liuli, Li Deng, Yanjun Liu, Yanjun Liu, Yanjun Liu, Yanjun Liu, Yanjun Liu, Tongtong Zhang, Tongtong Zhang, Tongtong Zhang, Tongtong Zhang, Tongtong Zhang, Di Xin, Yongmei Li, Zhonghui Feng, Zhonghui Feng, Zhonghui Feng, Zhonghui Feng, Zhonghui Feng   +32 more
doaj   +1 more source

Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice

eLife, 2017
Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective.
Chelsea Hepler, Mengle Shao, Jonathan Y Xia, Alexandra L Ghaben, Mackenzie J Pearson, Lavanya Vishvanath, Ankit X Sharma, Thomas S Morley, William L Holland, Rana K Gupta   +9 more
doaj   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Prevalence and influencing factors of different types of obesity among middle-aged and elderly Han and Tibetan residents in Gansu province: a cross-sectional study

Zhongguo gonggong weisheng
Objective To understand the prevalence and influencing factors of different types of obesity among middle-aged and elderly Han and Tibetan residents in Gansu province, and to provide evidence for the prevention and control of obesity.
Qian ZHANG, Binguo YAN, Tianhui TANG, Hangzhao FAN, Yi ZHAO, Yaqiong WANG, Ziyuan GAO, Jiahao HU, Leilei PEI, Fangyao CHEN, Shaonong DANG, Xinhua WANG, Hong YAN, Yaling ZHAO   +13 more
doaj   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Cost effective and adaptable measures of estimation of visceral adiposity

Clinical Epidemiology and Global Health, 2023
Background: Obesity is a major public health problem these days. Obesity, specifically visceral adiposity is linked to insulin resistance and an increased risk of cardiometabolic diseases.
Divya Elizabeth Mathew, Jonathan Arul Jeevan Jayakaran, Samuel George Hansdak, Ramya Iyadurai   +3 more
doaj   +1 more source

Health consequences of visceral obesity

Annals of Medicine, 2001
Visceral obesity is associated with metabolic abnormalities that increase the risk of type 2 diabetes and coronary heart disease. Obese patients with a substantial accumulation of visceral adipose tissue are characterized by higher insulinaemic and glycaemic responses during an oral glucose challenge as well as by a deteriorated plasma lipoprotein ...
openaire   +2 more sources

Clinical problems caused by obesity [PDF]

, 2010
Over the past few decades the incidence of obesity has doubled worldwide and current estimates classify more than 1.5 billion adults as overweight and at least 500 million of them as clinically obese, with body mass index (BMI) over 25 kg/m2 and 30 kg ...
Weickert, Martin O., Kyrou, Ioannis
core  

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source