Results 71 to 80 of about 666,764 (304)

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Association of Abdominal Myosteatosis and Visceral Fat Obesity with Arterial Stiffness [PDF]

Endocrinology and Metabolism
Background Arterial stiffness with aging predicts cardiovascular diseases (CVDs) and target organ damage. While sarcopenia has been linked to arterial stiffness, the association of myosteatosis and visceral adiposity with arterial stiffness remains ...
Min Jung Lee, Hong-Kyu Kim, Eun Hee Kim, Sung Jin Bae, Hyo-Jung Nam, Sang Hoon Lee, Chang Hee Jung, Woo Je Lee   +7 more
doaj   +1 more source

Self-reported disability in adults with severe obesity [PDF]

, 2011
Self-reported disability in performing daily life activities was assessed in adults with severe obesity (BMI ≥ 35 kg/m2) using the Health Assessment Questionnaire (HAQ).
N. Williams, Saravanan, Ponnusamy, Kyrou, Ioannis, R. Thomas, I. Kyrou, L. Halder, Osei-Assibey, G., S. Taheri, Thomas, R., Taheri, S., Williams, N., Halder, L., Saravanan, P., Kumar, Sudhesh, Williams, Nerys R., Kyrou, I., P. Saravanan, Halder, L. (Louise), S. Kumar, Kumar, S., G. Osei-Assibey   +20 more
core   +1 more source

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source

Osteosarcopenic Visceral Obesity and Osteosarcopenic Subcutaneous Obesity, Two New Phenotypes of Sarcopenia: Prevalence, Metabolic Profile, and Risk Factors

Journal of Aging Research, 2018
Background. The main criticism of the definition of “osteosarcopenic obesity” (OSO) is the lack of division between subcutaneous and visceral fat.
Simone Perna, Daniele Spadaccini, Mara Nichetti, Ilaria Avanzato, Milena Anna Faliva, Mariangela Rondanelli   +5 more
doaj   +1 more source

Visceral fat area is the measure of obesity best associated with mobility disability in community dwelling oldest-old Chinese adults

BMC Geriatrics, 2021
Background Although obesity can be clinically defined by body mass index (BMI), waist circumference, percent body fat, or visceral fat area, it is unclear which specific measure is best associated with mobility disability in oldest-old adults.
Kevin Yiqiang Chua, Xinyi Lin, Yeli Wang, Yap-Seng Chong, Wee-Shiong Lim, Woon-Puay Koh   +5 more
doaj   +1 more source

Obesity, visceral fat and Crohnʼs disease

Current Opinion in Clinical Nutrition and Metabolic Care, 2010
Increasing evidence indicates that adipose tissue is an active endocrine organ involved in metabolic syndrome and regulation of inflammation. Visceral fat accumulation is a hallmark of both obesity and Crohn's disease. Here, we present recent data describing the immune properties of intra-abdominal adipose tissue that could link the innate immune ...
Bertin, Benjamin, Desreumaux, Pierre, Dubuquoy, Laurent   +2 more
openaire   +2 more sources

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Predictors of visceral obesity in normal weight obstructive sleep apnea patients

Ожирение и метаболизм, 2019
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is epidemiologically related to adverse cardiovascular outcomes. The pathophysiology clues are metabolic changes and obesity.
Tatyana O. Brodovskaya, Egor A. Kovin, Oxana V. Bazhenova, Irina F. Grishina, Tatiana F. Peretolchina   +4 more
doaj   +1 more source

Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study: the Korean Sarcopenic Obesity Study (KSOS). [PDF]

PLoS ONE, 2014
Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited.
Tae Nyun Kim, Man Sik Park, Ja Young Ryu, Hae Yoon Choi, Ho Cheol Hong, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Seok Won Park, Sei Hyun Baik, Anne B Newman, Kyung Mook Choi   +11 more
doaj   +1 more source