Results 91 to 100 of about 4,678,799 (245)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Visible-Light-Activated Molecular Nanomachines Kill Pancreatic Cancer Cells

, 2019
Recently, synthetic molecular nanomachines (MNMs) that rotate unidirectionally in response to UV light excitation have been used to produce nanomechanical action on live cells to kill them through the drilling of holes in their cell membranes.
Robert Pal (1844038), Ciceron Ayala Orozco (8162310), Sunil Krishnan (2282686), James M. Tour (1274196), Dongdong Liu (409047), Lawrence B. Alemany (1276923), Yongjiang Li (1646131)   +6 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Visible-Light-Responsive Surface Molecularly Imprinted Polymer for Acyclovir through Chicken Skin Tissue

, 2018
The phototoxicity of UV light limits the application of conventional azobenzene-based photoresponsive molecularly imprinted polymers in the biomedical field.
Lantao Liu, Chengbin Gong, Nan Li, Chengbin Gong (2452663), Hailin Yang, Qian Tang (218689), Hailin Yang (5714378), Nan Li (155066), Lantao Liu (104405), Meijun Chen (5714375), Meijun Chen, Qian Tang   +11 more
core   +1 more source

Multi-Mobile Robot Localization and Navigation based on Visible Light Positioning [PDF]

, 2022
We demonstrated multi-mobile robot navigation based on Visible Light Positioning(VLP) localization.
Guan, Weipeng, Chen, Yanyi, Zhong, Zhiqing, Wen, Shangsheng   +3 more
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Visible Light Dynamic Positioning Method Using Improved Camshift-Kalman Algorithm

IEEE Photonics Journal, 2019
There are three critical elements in the visible light positioning (VLP) system: Positioning accuracy, real-time ability and robustness. However, few existing VLP studies consider these three critical elements at the same time.
Weipeng Guan, Zhipeng Liu, Shangsheng Wen, Hongyun Xie, Xingjie Zhang   +4 more
doaj   +1 more source

Unmodulated Visible Light Positioning using the Iterated Extended Kalman Filter

, 2018
With the rise of solid state lighting, wireless positioning based on visible light is becoming more appealing. However, current visible light positioning systems require additional hardware at the transmitter end in order to modulate the light intensity.
Stevens, Nobby, Peter Slaets, Slaets, Peter, Eric Demeester, Nobby Stevens, Amsters, Robin, Robin Amsters, Demeester, Eric   +7 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source