Results 101 to 110 of about 57,426 (277)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Visible Light indoor positioning through colored LEDs

, 2017
The need to manage connectivity, when Internet access is granted indoor via Visible Light Communications, leads to acquire information about user position.
Ghassemlooy, Zabih, Vegni, Anna Maria, Biagi, Mauro, Anna Maria Vegni, Mauro Biagi, Mohamadi, Zeinab, Pergoloni, Stefano, Zeinab Mohamadi, Zabih Ghassemlooy, Stefano Pergoloni   +9 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Towards Automated Calibration of Visible Light Positioning Systems

, 2019
Localization based on visible light is a novel technique for indoor positioning that provides a number of advantages over traditional radio frequency based approaches.
Stevens, Nobby, Joren Joly, Joly, Joren, Peter Slaets, Slaets, Peter, Eric Demeester, Dimiter Holm, Nobby Stevens, Amsters, Robin, Holm, Dimiter, Robin Amsters, Demeester, Eric   +11 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Applied Visible Light Positioning

, 2021
Positioning is not a new problem. Humanity has attempted to determine its location for centuries with tools such as sextants, clocks, maps, and more. One of the largest revolutions in this field is arguably the advent of the global positioning system (GPS), which can provide position information almost anywhere on earth.
openaire   +1 more source

An Indoor Visible Light Positioning System Using Artificial Neural Network

, 2018
We propose a visible light positioning system based on an artificial neural network (ANN) and optical camera communications. The receiver’s position is approximately and precisely estimated based on the decoded block coordinate and a typical back ...
Haiguang Zhang, Tang, Xuan, Lin, Bangjiang, Ghassemlooy, Zabih, Lin, Chun, Bangjiang Lin, Sushank Chaudhary, Chun Lin, Xuan Tang, Zhenlei Zhou, Chaudhary, Sushank, Zhou, Zhenlei, Zabih Ghassemlooy   +12 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source