Results 91 to 100 of about 5,784 (166)

Pharmacokinetic–Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation

, 2011
Purpose: Vismodegib (GDC-0449) is a potent and selective inhibitor of the Hedgehog (Hh) pathway that shows antitumor activity in preclinical models driven by mutational or ligand-dependent activation of the Hh pathway.
Patricia Pacheco, Frederic J. de Sauvage, Harvey Wong, Robert L. Yauch, Kristina A. West, Hank La, Bruno Alicke, Stephen E. Gould, Tom Januario   +8 more
core   +1 more source

Table_1_Deciphering the Allosteric Effect of Antagonist Vismodegib on Smoothened Receptor Deactivation Using Metadynamics Simulation.DOCX

, 2019
The smoothened receptor (Smo) plays a key role in Hedgehog (Hh) signaling pathway and it has been regarded as an efficacious therapeutic target for basal cell carcinoma (BCC) and medulloblastoma (MB).
Qifeng Bai (220551), Huanxiang Liu (418534), Xiaoli An (4438792), Danfeng Shi (838463), Fang Bai (1612534), Xiaojun Yao (220558)   +5 more
core   +1 more source

Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series

Case Reports in Dermatology
Introduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma (BCC), characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area, and ears, representing 1.2–2.7% of all head ...
Enrico Bocchino, Simone Cappilli, Gerardo Palmisano, Andrea Paradisi, Alfredo Piccerillo, Alessandro Di Stefani, Ketty Peris   +6 more
doaj   +1 more source

Vismodegib for advanced basal cell carcinoma treatment

, 2017
Trabalho de Projeto do Mestrado Integrado em Medicina apresentado à Faculdade de MedicinaO carcinoma basocelular é a neoplasia humana mais frequente e a sua incidência tem aumentado mundialmente.
Xavier, Marta Martins
core  

Hedgehog pathway inhibitors for locally advanced and metastatic basal cell carcinoma: A real-world single-center retrospective review.

PLoS ONE
Basal cell carcinoma (BCC) is highly curable by surgical excision or radiation. In rare cases, BCC can be locally destructive or difficult to surgically remove. Hedgehog inhibition (HHI) with vismodegib or sonidegib induces a 50-60% response rate.
Shivani Patel, Heather Armbruster, Gretchen Pardo, Brianna Archambeau, Na Hyun Kim, Joanne Jeter, Richard Wu, Kari Kendra, Carlo M Contreras, Natalie Spaccarelli, Brittany Dulmage, Llana Pootrakul, David R Carr, Claire Verschraegen   +13 more
doaj   +1 more source

A case of a patient with severe renal failure on hemodialysis treated with vismodegib for relapsing basal cell carcinoma

, 2018
Introduction: Basal cell carcinoma (BCC) is the most common skin cancer. Treatment options for metastatic or locally advanced BCC inappropriate for surgery or radiotherapy were poor until vismodegib was approved for use in this setting.
Luca Galli, Sergio Ricci, Andrea Sbrana, Federico Paolieri, Andrea Antonuzzo, Elisa Biasco, Gianna Musettini   +6 more
core   +1 more source

Supplementary figure s5 from Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma

, 2016
Vismodegib does not interfere with in vivo Bli ...
Bart Vrugt (802090), Karima Bérard (15073989), Angela Broggini-Tenzer (112742), Stephan Arni (11218423), Emanuela Felley-Bosco (82830), David Kenkel (829672), Rolf A. Stahel (14992155), Isabelle Opitz (802092), Andreas Boss (393288), Mayura Meerang (15040088), Olivia Lauk (838999), Walter Weder (802091)   +11 more
core   +1 more source

Síndrome de Gorlin con carcinoma basocelular metastásico en tratamiento con vismodegib [PDF]

, 2019
The Gorlin-Goltz syndrome or basal cell nevoid carcinoma syndrome is a rare autosomal dominant disorder characterized by odontogenic keratocysts of the jaw, plantar or palmar pits and multiple basal cell carcinomas (BCC).
Velásquez, Juan Carlos, González, Diego Mauricio, Galvis, Luisa Alejandra, Pulido, Leonardo   +3 more
core  

Advanced Periocular Basal Cell Carcinoma with Orbital Invasion: Update on Management and Treatment Advances

Journal of Ophthalmology
Purpose. Basal cell carcinoma (BCC) is the most frequent malignant periocular tumor. It is associated with exposure to ultraviolet radiation, and its incidence is gradually increasing.
Alvaro Bengoa-González, Enrique Mencía-Gutiérrez, María Garrido, Elena Salvador, María-Dolores Lago-Llinás   +4 more
doaj   +1 more source

Profile of vismodegib and its potential in the treatment of advanced basal cell carcinoma

Cancer Management and Research, 2013
Muzafar A Macha,1 Surinder K Batra,1,2 Apar Kishor Ganti3,41Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, 2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical ...
Macha MA, Batra SK, Ganti AK
doaj