Results 11 to 20 of about 5,401 (177)

A Phase 1b Study of Vismodegib with Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Pulmonary Therapy, 2019
Introduction Components of the hedgehog signaling pathway are upregulated in patients with idiopathic pulmonary fibrosis (IPF). Vismodegib, a small-molecule inhibitor of hedgehog signaling, when used in combination with currently available antifibrotic ...
Antje Prasse, Murali Ramaswamy, Shaun Mohan, Lin Pan, Andrew Kenwright, Margaret Neighbors, Paula Belloni, Peter P. LaCamera   +7 more
doaj   +2 more sources

Exploring vismodegib: A non-surgical breakthrough in the management of advanced periocular basal cell carcinoma

Cancer Treatment and Research Communications
The management of periocular basal cell carcinoma (BCC) is challenging due to its proximity to the eyeball. Vismodegib, a Hedgehog pathway inhibitor, has emerged as a therapeutic option for locally advanced and metastatic BCC.
Georgios Lavasidis, Argyrios Tzamalis, Ioannis Tsinopoulos, Nikolaos Ziakas   +3 more
doaj   +2 more sources

Giant morphea-form basal cell carcinoma of the umbilicus: Successful debulking with vismodegib [PDF]

Rare Tumors, 2018
Basal cell carcinoma of the umbilicus is very rare. The nodular subtype is the main representative. Giant basal cell carcinomas represent around 1% of all basal cell carcinomas.
Mariana Orduz Robledo, Eve Lebas, Marie-Annick Reginster, Mahmoud Baghaie, Sabine Groves, Arjen F Nikkels   +5 more
doaj   +2 more sources

Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face [PDF]

Case Reports in Oncological Medicine, 2015
Background. For large basal cell carcinomas (BCCs) of the head and neck, definitive surgery often requires extensive resection and reconstruction that may result in prolonged recovery and limited cosmesis.
Alec M. Block, Fiori Alite, Aidnag Z. Diaz, Richard W. Borrowdale, Joseph I. Clark, Mehee Choi   +5 more
doaj   +2 more sources

Real-world experience with vismodegib and sonidegib in advanced basal cell carcinoma: a multicenter Italian study [PDF]

Dermatology Reports
Vismodegib and sonidegib are smoothened (SMO) inhibitors approved for the treatment of advanced basal cell carcinoma (aBCC). This study investigates the real-world experiences and outcomes associated with these therapies across multiple Italian centers ...
Mario Valenti, Sara Di Giulio, Andrea Carugno, Pasquale Frascione, Angelo Valerio Marzano, Santo Raffaele Mercuri, Gianluca Nazzaro, Giulia Spallone, Giovanni Paolino, Marco Ardigò   +9 more
doaj   +2 more sources

Vismodegib for Locally Advanced Periocular and Orbital Basal Cell Carcinoma: A Review of 15 Consecutive Cases

Plastic and Reconstructive Surgery, Global Open, 2017
Summary:. Basal cell carcinoma (BCC) is the most common periocular skin cancer and can lead to significant morbidity. We assess the effectiveness of vismodegib, a first-in-class Hedgehog signaling pathway inhibitor, in the management of periocular and ...
Kai Yuen Wong, MA, MRCS, Kate Fife, MD, FRCP, FRCR, John T. Lear, MD, FRCP, Richard D. Price, MD, FRCS (Plast), Amer J. Durrani, MSc, FRCS (Plast)   +4 more
doaj   +2 more sources

Vismodegib no Tratamento do Carcinoma Basocelular Avançado – Experiência de 3 Casos

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2016
O carcinoma basocelular é a neoplasia cutânea mais comum, e a sua incidência tem vindo a aumentar nas últimas décadas. O tratamento de eleição é a cirurgia, podendo em casos selecionados optar-se pela radioterapia como tratamento de intenção curativa, ou
Ana Gameiro, Miguel Gouveia, Ana Brinca, Maria Manuel Brites, Ricardo Vieira, Américo Figueiredo   +5 more
doaj   +3 more sources

Mohs Surgery Outcomes for Basal Cell Carcinoma Treated With Neoadjuvant Sonic Hedgehog Inhibitor. [PDF]

Int J Dermatol
International Journal of Dermatology, Volume 65, Issue 7, Page 1493-1494, July 2026.
Barnawi G, Lazarowitz R, Aly S, Nukaly H, Weiss E.   +4 more
europepmc   +2 more sources

Metastatic Basal Cell Carcinoma With Unusual Molecular Genetics Findings. [PDF]

Clin Case Rep
ABSTRACT Basal cell carcinoma (BCC) rarely metastasizes to other parts of the body. When metastasis occurs, it usually involves regional lymph nodes. BCC lesions located in the head and neck region have been shown to spread to cervical lymph nodes.
Al-Hail N, Al-Abdulla M, Rizvi S, Al-Hayki N.   +3 more
europepmc   +2 more sources

Inhibition of CAL27 Oral Squamous Carcinoma Cell by Targeting Hedgehog Pathway With Vismodegib or Itraconazole

Frontiers in Oncology, 2020
Oral Squamous Cell Carcinoma (OSCC) presents an important challenge for the health systems worldwide. Thus, unraveling the biological mechanisms involved in OSCC pathogenesis is essential to the discovery of new drugs with anticancer potential.
Raíza Dias Freitas, Raíza Dias Freitas, Rosane Borges Dias, Rosane Borges Dias, Manuela Torres Andion Vidal, Manuela Torres Andion Vidal, Ludmila de Faro Valverde, Ludmila de Faro Valverde, Rafaela Gomes Alves Costa, Andresa Karen Andrade Damasceno, Caroline Brandi Schlaepfer Sales, Leonardo de Oliveira Siquara da Rocha, Mitermayer Galvão dos Reis, Mitermayer Galvão dos Reis, Milena Botelho Pereira Soares, Ricardo Della Coletta, Thiago Almeida Pereira, Daniel Pereira Bezerra, Clarissa Araújo Gurgel Rocha, Clarissa Araújo Gurgel Rocha, Clarissa Araújo Gurgel Rocha   +20 more
doaj   +1 more source