Results 31 to 40 of about 5,784 (166)

Long-Term Efficacy of Vismodegib After its Withdrawal and Patients’ Health-Related Quality of Life Using the Dermatology Life Quality Index (DLQI)

Dermatology and Therapy, 2019
Introduction Although non-melanoma skin cancers (NMSCs) are associated with a very low mortality risk, they have been reported to have a major impact on patients’ health-related quality of life (HRQoL).
Alessia Villani, Matteo Megna, Gabriella Fabbrocini, Milena Cappello, Maria Antonietta Luciano, Claudia Costa, Massimiliano Scalvenzi   +6 more
doaj   +1 more source

Eight years of experience with vismodegib for advanced and multiple basal cell carcinoma patients in the Netherlands:a retrospective cohort study [PDF]

, 2021
BACKGROUND: Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials.
Devriese, Lot A, Mosterd, K, Aarts, M.J.B., Reinders, M, Racz, Emoke, Alers, R.J., Verkouteren, Babette J. A., Racz, E., Bekkenk, Marcel W, Kapiteijn, E, Reyners, AKL, Aarts, MJB, Nelemans, P., Reyners, An K L, Devriese, Lot A., Bekkenk, M.W., van Doorn, Remco, Verkouteren, B.J.A., Bekkenk, MW, Mosterd, Klara, Devriese, LA, Aarts, Maureen J B, Alers, RJ, Devriese, L.A., van Doorn, R., Kapiteijn, Ellen, Alers, Robert-Jan, Bekkenk, Marcel W., Terra, J.B., Mosterd, K., Verkouteren, BJA, Terra, Jorrit B., Terra, JB, Racz, Emoke; id_orcid, Kapiteijn, E., Terra, Jorrit B, Reinders, Marie G H C, Aarts, Maureen J. B., Wakkee, M., Doorn, R. van, Reyners, An K. L.; id_orcid, Reyners, A.K.L., Wakkee, Marlies, Nelemans, Patty, van Doorn, R, Reinders, M.G.H.C., Reinders, Marie G. H. C., Nelemans, P, Verkouteren, Babette J A, MS Medische Oncologie, Cancer, Patty Nelemans, Klara Mosterd, Remco van Doorn, Marie G.H.C. Reinders, Maureen J. B. Aarts, Marcel W. Bekkenk, Emőke Rácz, Marlies Wakkee, Ellen Kapiteijn, Jorrit B. Terra, An K. L. Reyners, Babette J. A. Verkouteren, Lot A. Devriese, Robert-Jan Alers   +64 more
core   +1 more source

Treatment of Basal Cell Carcinoma with Vismodegib [PDF]

, 2019
The most prevalent nonmelanoma skin cancers are basal cell carcinoma (BCC) and locally advanced basal cell carcinoma (aBCC). Current, effective first-line treatments for BCC aim to remove and destroy cancerous skin cells through excision surgery, Mohs ...
Chrissobolis, Sophocles, Dao Le, Anh, Brown, Katlyn, Johns, Sunitha, Loudermilk, Emily, Zheng, Crystal   +5 more
core   +1 more source

A Phase 1b Study of Vismodegib with Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Pulmonary Therapy, 2019
Introduction Components of the hedgehog signaling pathway are upregulated in patients with idiopathic pulmonary fibrosis (IPF). Vismodegib, a small-molecule inhibitor of hedgehog signaling, when used in combination with currently available antifibrotic ...
Antje Prasse, Murali Ramaswamy, Shaun Mohan, Lin Pan, Andrew Kenwright, Margaret Neighbors, Paula Belloni, Peter P. LaCamera   +7 more
doaj   +1 more source

Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib [PDF]

, 2020
Background: Vismodegib, a first-in-class Hedgehog pathway inhibitor, was US Food and Drug Administration (FDA) approved for advanced basal cell carcinomas (BCCs) based on a single, nonrandomized, phase-II trial. Consequently, additional clinical data are
Anne Lynn, Ormond Beach, MD Glen J Weiss, Texas; Illinois ; Houston, PharmD, BCOP Edward Mckenna, H Stanford, Tennessee ; Urbana, San Francisco, California ; Scottsdale, PhD Bann-Mo Day, MD S Chang, California ;, Orlando, MD John D Hainsworth, MD Diana M Chen, MD James A Solomon, MD Leonard Goldberg, Arizona, Florida ; Nashville   +18 more
core   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Vismodegib: the Proof of Concept in Basal Cell Carcinoma

, 2014
Although basal cell carcinoma (BCC) is the most common cancer worldwide, its metastatic dissemination is exceptional. Before 2012, we had a few treatment options available for metastatic or locally advanced cases.
Siham Lkhoyali, Narjiss Berrada, Hassan Errihani, Hind Mrabti   +3 more
core   +1 more source

24 | Management of advanced basal cell carcinoma with hedgehog inhibitors: a real-world prospective comparative study

Dermatology Reports
Background: Hedgehog Pathway Inhibitors (HHIs) should be offered to patients with advanced BCC as a first line treatment. Two systemic HHIs are currently available: sonidegib and vismodegib.
Italian Melanoma Intergroup
doaj   +1 more source

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source

Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis

Cell Death and Disease, 2023
Macrophages are the origin of most foam cells in the early stage of atherosclerotic plaques. However, the mechanism involved in the formation of macrophage-derived foam cell formation remains unclear. Here, we revealed that the hedgehog (Hh) signaling is
Yuting Zhang, Weijuan Xin, Xiaozhi Hu, Hanqi Wang, Xiaomiao Ye, Caili Xu, Yanyang Nan, Zhengyu Wu, Dianwen Ju, Jiajun Fan   +9 more
doaj   +1 more source