Results 61 to 70 of about 629,636 (267)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Portable, precise, and RNA extraction-free: RT-RAA technology for rapid early RSV identification and prevention

Frontiers in Cellular and Infection Microbiology
The Respiratory Syncytial Virus (RSV) is a significant agent linked to respiratory infections, representing a considerable health risk for vulnerable populations, including infants, older adults, and those with weakened immune systems.
Zhenfei Wang, Jing Zhang, Xiao He, Chunming Wang, Zhenyue Li, Zitong Yang, Cheng Zhang, Tingli Fan, Kai Su   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Facile Fluorescent Visualization Method Based on Copper Clusters for Formaldehyde Detection

Molecules
Establishing a simple and effective method for the visual detection of formaldehyde plays an important role in environmental emergency monitoring. In this work, L-cysteine-stabilized copper clusters were synthesized via a green, mild, and facile one-step
Jie Zou, Qing Chen, Guimin Mu, Miao Ma, Fang Yang, Mengtian Li, Fujian Xu, Hui Xia   +7 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

RPA-CRISPR/Cas12a-based detection of Pasteurella multocida: establishment and initial application

Frontiers in Veterinary Science
IntroductionPasteurella multocida (Pm) is a major pathogen that causes respiratory diseases in sheep, leading to high morbidity, high mortality, and significant economic losses. Current diagnostic methods, such as bacterial isolation, ELISA, and PCR, are
Chaoqun Yan, Chaoqun Yan, Xiaozhen Li, Rulong Chen, Quanxin Wu, Quanxin Wu, Youquan Zhuang, Youquan Zhuang, Na Li, Xuelian Ma, Yuefeng Chu, Yuefeng Chu, Huijun Shi, Huijun Shi, Qiang Fu, Qiang Fu, Li Yang, Li Yang, Li Yang   +18 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A rapid and visual dual LAMP-LFD assay for on-site simultaneous detection of influenza A virus (H1N1) and respiratory syncytial virus (RSV)

Frontiers in Microbiology
Respiratory tract infections caused by influenza A virus (IAV) and respiratory syncytial virus (RSV) are a major global health burden. To overcome the limitations of existing diagnostic techniques for timely detection (point-of-care testing), this study ...
Alang Zhang, Xingyu Lan, Hengxuan Zhou, Ting Zhou, Zhihua Xu, Xinyu Cheng, Chenxi Guo, Mingjie Wei, Jiahui Wu, Feng Shi   +9 more
doaj   +1 more source

Airborne Visual Detection and Tracking of Cooperative UAVs Exploiting Deep Learning

Sensors, 2019
The performance achievable by using Unmanned Aerial Vehicles (UAVs) for a large variety of civil and military applications, as well as the extent of applicable mission scenarios, can significantly benefit from the exploitation of formations of vehicles ...
Roberto Opromolla, Giuseppe Inchingolo, Giancarmine Fasano   +2 more
doaj   +1 more source

Dynamic Detection Of Visual Entities

, 2012
Publication in the conference proceedings of EUSIPCO, Bucharest, Romania ...
Andrei Bursuc, Titus Zaharia, Françoise J. Prêteux   +2 more
openaire   +3 more sources