Results 61 to 70 of about 384,676 (291)

Social care and support needs of community-dwelling people with dementia and concurrent visual impairment [PDF]

open access: yes, 2017
Objectives: Little is known about the needs of people who have both dementia and visual impairment. This study explored the social care and support needs of people with dementia and concurrent visual impairment, and the barriers and facilitators for ...
Heward, Michelle   +2 more
core   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

SHP-2-Induced Activation of c-Myc Is Involved in PDGF-B-Regulated Cell Proliferation and Angiogenesis in RMECs

open access: yesFrontiers in Physiology, 2020
Background: Aberrant neovascularization resulting from inappropriate angiogenic signaling is closely related to many diseases, such as cancer, cardiovascular disease, and proliferative retinopathy.
Jun Ma   +10 more
doaj   +1 more source

No-reference bitstream-based visual quality impairment detection for high definition H.264/AVC encoded video sequences [PDF]

open access: yes, 2012
Ensuring and maintaining adequate Quality of Experience towards end-users are key objectives for video service providers, not only for increasing customer satisfaction but also as service differentiator.
Crombecq, Karel   +8 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy

open access: yesBMC Ophthalmology, 2018
Background While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily.
Yinghong Ji, Xianfang Rong, Yi Lu
doaj   +1 more source

Heterogeneity of Axenfeld–Rieger Syndrome: Molecular and Clinical Findings in Chinese Patients

open access: yesFrontiers in Genetics, 2021
Axenfeld–Rieger Syndrome (ARS) is a rare disease with a wide spectrum of ocular and systemic manifestations. The genetic spectrum of Chinese patients with ARS and genotype-phenotype correlations have yet to be described.
Youjia Zhang   +8 more
doaj   +1 more source

Elimination of avoidable blindness due to cataract: where do we prioritize and how should we monitor this decade? [PDF]

open access: yes, 2012
BACKGROUND: In the final push toward the elimination of avoidable blindness, cataract occupies a position of eminence for the success of the Right to Sight initiative. AIMS: Review existing situation and assess what monitoring indicators may be useful to
John, Neena   +3 more
core   +2 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

A review of visual impairment

open access: yesAfrican Vision and Eye Health, 2018
Visual impairment (VI), a global concern that is likely to escalate with prolonged life expectancies, has gained increasing attention in the realm of eye care. The purpose of this article is to highlight the different aspects of VI, including its definition and characteristics, prevalence, causes and implications.
Nishanee Rampersad, Shivani Naipal
openaire   +3 more sources

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