Results 61 to 70 of about 4,116,225 (362)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Reversal learning is influenced by cognitive flexibility and develops throughout early adolescence

npj Science of Learning
Learning behavioural responses and adapting them based on feedback is crucial from a young age, continuing to develop into young adulthood. This study examines the development trajectory and contributing factors from childhood to adulthood using a ...
Christoph Bamberg, Sarah Weigelt, Klara Hagelweide   +2 more
doaj   +1 more source

Replication of the Association Between Keratoconus and Polymorphisms in PNPLA2 and MAML2 in a Han Chinese Population

Frontiers in Genetics, 2020
Keratoconus (KC) is a complex ocular disease that is affected by both genetic and non-genetic triggers. A recent genome-wide association study (GWAS) identified a genome-wide significant locus for KC in the region of PNPLA2 (rs61876744), as well as a ...
Jing Zhang, Jing Zhang, Jing Zhang, Yue Li, Yue Li, Yue Li, Yiqin Dai, Yiqin Dai, Yiqin Dai, Jianjiang Xu, Jianjiang Xu, Jianjiang Xu   +11 more
doaj   +1 more source

The Health Related Components of Physical Fitness in People with Visual Impairment: A Systematic Review [PDF]

, 2019
Visual impairment is becoming progressively more common in America’s aging society. Physical inactivity contributes to the development of chronic health conditions.
Bell, Sarah, Peterson, Janet T.
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Comparing objective visual quality impairment detection in 2D and 3D video sequences [PDF]

, 2012
The skill level of teleoperator plays a key role in the telerobotic operation. However, plenty of experiments are required to evaluate the skill level in a conventional assessment.
Boussaer, Arnaud, Demeester, Piet, Staelens, Nicolas, Van hoogenbemt, Geert, Vercammen, Nick, Vermeulen, Brecht   +5 more
core   +2 more sources

Cytokine profiles in the aqueous humor of uveal melanoma: implications for tumor progression and radiation response

Frontiers in Medicine
PurposeThis study aimed to investigate the cytokine profile in the aqueous humor of uveal melanoma (UM) and explore the role of cytokines in tumor progression and radiation response.MethodsAqueous humor samples were collected from patients with UM who ...
Jie Ding, Jie Ding, Han Yue, Han Yue, Binbin Xu, Binbin Xu, Lianyao Shi, Jie Guo, Jie Guo, Jiang Qian, Jiang Qian   +10 more
doaj   +1 more source

Varying Clinical Phenotypes of Mitochondrial DNA T12811C Mutation: A Case Series Report

Frontiers in Medicine, 2022
The T12811C mitochondrial DNA (mtDNA) mutation has been reported in Leber hereditary optic neuropathy (LHON) previously, with vision loss as the main manifestation.
Qingdan Xu, Ping Sun, Chaoyi Feng, Qian Chen, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Yuhong Chen, Yuhong Chen, Guohong Tian, Guohong Tian   +10 more
doaj   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

MicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model

BMC Ophthalmology
Introduction Retinal ganglion cells (RGCs) are susceptible to degenerative conditions such as glaucoma and traumatic optic neuropathies, which lead to vision loss.
Qing Xia, Wei Chen, Jiawei Xiong, Xiaofen Mo   +3 more
doaj   +1 more source