Results 61 to 70 of about 690,818 (341)

The profiles and clinical significance of extraocular muscle-expressed lncRNAs and mRNAs in oculomotor nerve palsy

Frontiers in Molecular Neuroscience, 2023
IntroductionOculomotor nerve palsy (ONP) arises from primary abnormalities in the central neural pathways that control the extraocular muscles (EOMs).
Lianqun Wu, Lianqun Wu, Lianqun Wu, Mingsu Shi, Mingsu Shi, Mingsu Shi, Yu Liang, Yu Liang, Yu Liang, Jiaqiu Huang, Jiaqiu Huang, Jiaqiu Huang, Weiyi Xia, Weiyi Xia, Weiyi Xia, Hewei Bian, Hewei Bian, Hewei Bian, Qiao Zhuo, Qiao Zhuo, Qiao Zhuo, Chen Zhao, Chen Zhao, Chen Zhao   +23 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

MicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model

BMC Ophthalmology
Introduction Retinal ganglion cells (RGCs) are susceptible to degenerative conditions such as glaucoma and traumatic optic neuropathies, which lead to vision loss.
Qing Xia, Wei Chen, Jiawei Xiong, Xiaofen Mo   +3 more
doaj   +1 more source

Prevelence and causes of visual impairment and blindness in older adults in an area of India with a high cataract surgical rate.

, 2010
BACKGROUND: The cataract surgical rate (CSR) in Gujarat, India is reported to be above 10,000 per million population. This study was conducted to investigate the prevalence and causes of vision impairment/blindness among older adults in a high CSR area ...
Ellwein, Leon B, John, Neena, Murthy, Gudlavalleti VS, Pokharel, Gopal, Vashist, Praveen   +4 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

SHP-2-Induced Activation of c-Myc Is Involved in PDGF-B-Regulated Cell Proliferation and Angiogenesis in RMECs

Frontiers in Physiology, 2020
Background: Aberrant neovascularization resulting from inappropriate angiogenic signaling is closely related to many diseases, such as cancer, cardiovascular disease, and proliferative retinopathy.
Jun Ma, Jun Ma, Wenyi Tang, Ruiping Gu, Fangyuan Hu, Fangyuan Hu, Lei Zhang, Jihong Wu, Jihong Wu, Gezhi Xu, Gezhi Xu   +10 more
doaj   +1 more source

Heterogeneity of Axenfeld–Rieger Syndrome: Molecular and Clinical Findings in Chinese Patients

Frontiers in Genetics, 2021
Axenfeld–Rieger Syndrome (ARS) is a rare disease with a wide spectrum of ocular and systemic manifestations. The genetic spectrum of Chinese patients with ARS and genotype-phenotype correlations have yet to be described.
Youjia Zhang, Youjia Zhang, Xueli Chen, Li Wang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Yuhong Chen, Yuhong Chen   +8 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy

BMC Ophthalmology, 2018
Background While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily.
Yinghong Ji, Xianfang Rong, Yi Lu
doaj   +1 more source