Results 71 to 80 of about 384,676 (291)

Common mental illness in people with sensory impairment: results from the 2014 adult psychiatric morbidity survey [PDF]

, 2019
BACKGROUND: People with sensory impairments may be at increased risk of depression and anxiety but experience barriers to accessing treatment. AIMS: To investigate whether people with sensory impairment have more depressive and anxiety symptoms than ...
Hodge, Leigh, McManus, McManus, Nelson
core   +2 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Direct and indirect effects of attention and visual function on gait impairment in Parkinson's disease: influence of task and turning [PDF]

, 2017
Gait impairment is a core feature of Parkinson's disease (PD) which has been linked to cognitive and visual deficits, but interactions between these features are poorly understood.
Delicato, Louise S., Foxe, John, Galna, Brook, Lord, Sue, Rochester, Lynn, Stuart, Sam   +5 more
core   +4 more sources

Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalk

Stem Cell Research & Therapy
Background Stem cell-derived secreted factors could protect neurons in neurodegenerative disease or after injury. The exact neuroprotective components in the secretome remain challenging to discover.
Qing Xia, Kun-Che Chang, Yanan Sun, Michael Nahmou, Takahiko Noro, Yun Cheng, Xiangmei Kong, Xiaofen Mo, Jeffrey L. Goldberg, Suqian Wu   +9 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

An Optical Coherence Tomography-Based Deep Learning Algorithm for Visual Acuity Prediction of Highly Myopic Eyes After Cataract Surgery

Frontiers in Cell and Developmental Biology, 2021
BackgroundDue to complicated and variable fundus status of highly myopic eyes, their visual benefit from cataract surgery remains hard to be determined preoperatively.
Ling Wei, Ling Wei, Ling Wei, Wenwen He, Wenwen He, Wenwen He, Jinrui Wang, Keke Zhang, Keke Zhang, Keke Zhang, Yu Du, Yu Du, Yu Du, Jiao Qi, Jiao Qi, Jiao Qi, Jiaqi Meng, Jiaqi Meng, Jiaqi Meng, Xiaodi Qiu, Xiaodi Qiu, Xiaodi Qiu, Lei Cai, Lei Cai, Lei Cai, Qi Fan, Qi Fan, Qi Fan, Zhennan Zhao, Zhennan Zhao, Zhennan Zhao, Yating Tang, Yating Tang, Yating Tang, Shuang Ni, Haike Guo, Yunxiao Song, Xixi He, Dayong Ding, Yi Lu, Yi Lu, Yi Lu, Xiangjia Zhu, Xiangjia Zhu, Xiangjia Zhu   +44 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Why are there gender inequalities in visual impairment? [PDF]

, 2018
Background In high-income countries, the prevalence of blindness and visual impairment is higher among women, regardless of age although the mechanisms that produce these gender inequalities are not well understood.
Artazcoz Lazcano, Lucía, Benach de Rovira, Joan, Guisasola València, Laura, Rius Ulldemolins, Anna   +3 more
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Gender difference in the relationships between vision and hearing impairments and negative well-being.

, 2008
OBJECTIVES: To evaluate the association of hearing impairment, vision impairment and their combination (dual sensory impairment) with negative well-being such as depression, subjective poor health and the reduced functional ability in community-dwelling ...
Harada, Sei, Ishigami, Ai, Iwasawa, Satoko, Kikuchi, Yuriko, Michikawa, Takehiro, Nakano, Makiko, Nishiwaki, Yuji, Saito, Hideyuki, Takebayashi, Toru   +8 more
core   +1 more source