Results 101 to 110 of about 4,664,382 (261)

Clinical profile and predictors of visual outcome in nonarteritic anterior ischemic optic neuropathy

Kerala Journal of Ophthalmology, 2018
Background: Nonarteritic anterior ischemic optic neuropathy (NAION) is a disorder of the optic nerve head causing acute painless visual loss in the elderly. Several ocular and systemic risk factors predispose to optic nerve head ischemia.
P T Jyothi, S Bindu, Padma B Prabhu
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Pediatric ocular trauma leading to cataract: A decade of clinical and epidemiologic outcome

Journal of Clinical Ophthalmology and Research
Introduction: Pediatric traumatic cataract is a major cause of preventable childhood visual impairment, particularly in underserved rural populations. Understanding its epidemiology and outcomes is crucial for developing effective interventions. Methods:
Mehul A. Shah, Shreya M. Shah, Riddhi Shah, Nikita Balani, Suprabha Chandran   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

When Drift becomes Current: Collaborating to Expand Beyond the Visual [PDF]

, 2020
In 2015, SUNY Purchase College art librarian Kim Detterbeck reimagined a long-standing part-time Visual Resources position into a full-time Digital Collections Curator position.
Oliver, Mēgan, Detterbeck, Kimberly
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STUDY THE FREQUENCY OF ANAEMIA IN PATIENTS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS IMPACT ON HEALTH RELATED QUALITY OF LIFE

National Journal of Medical Research, 2015
Background: This is a prospective study of ocular trauma profile related to road traffic accidents that presented to a tertiary care centre in Western Maharashtra.
Abha Gahlot, Renu Magdum, Manisha Singh, Priti Kumari   +3 more
doaj  

Clinical Outcomes of Multiple-Shot Nd:YAG Laser Hyaloidotomy for Premacular Subhyaloid Haemorrhage in Proliferative Diabetic Retinopathy

TNOA Journal of Ophthalmic Science and Research
Aim: To evaluate the efficacy of Nd:YAG laser hyaloidotomy using multiple shots for organized premacular subhyaloid haemorrhage with clotted blood in proliferative diabetic retinopathy (PDR). Methods: This interventional case series included 15 eyes. Pre
B. Koshal Ram, Anusha K. Ram, S. Balasubramanian   +2 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Visual Resources Association Treasurer's 2018 Report [PDF]

, 2020
The 2018 Treasurer's Report was presented at the Annual Membership & Business Meeting at the VRA2018 conference in Philadelphia on March 28, 2018. It outlines the previous year's budget activity as well as steps taken to secure the Visual Resources ...
Keefer PhD, Jeannine
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