Results 61 to 70 of about 3,542,402 (295)
Reactome enhanced pathway visualization [PDF]
Bioinformatics, 2017 Abstract Motivation Reactome is a free, open-source, open-data, curated and peer-reviewed knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical structure that largely corresponds to the GO biological process hierarchy, allowing the user to navigate from high level concepts ...
Konstantinos Sidiropoulos +18 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Declined contrast sensitivity of neurons along the visual pathway in aging cats
Frontiers in Aging Neuroscience, 2014 Changes in the visual cortex appear to mediate much of the visual degradation during normal aging. However, how aging affects different stages along the visual pathway is unclear.
Zhengchun eWang +6 more
doaj +1 more source
Dyslexia and the assessment of visual attention [PDF]
, 2011 Visual stream segregation has been proposed as a method to measure visual attention in dyslexia. Another task proposed to do this is the line-motion illusion. Both tasks, it is observed, can be carried out with spatially distributed stimuli.
John Skoyles, Bernt C. Skottun
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Threat modulates perception of looming visual stimuli [PDF]
, 2012 SummaryAmong the most critical of visual functions is the detection of potentially hazardous or threatening aspects of the environment. For example, objects on a collision course with an observer must be quickly identified to allow sufficient time to ...
Longo, Matthew R. +3 more
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
The Effects of Different Phase on Independent Visual Fields SSVEP Responses
IEEE Transactions on Neural Systems and Rehabilitation EngineeringBinocular disparate stimulation based on steady-state visual evoked potentials (SSVEP) generates more recognizable features but also introduces complexity hardening the interpretability of SSVEP responses.
Dalu Zheng +4 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PharmaceuticalsBackground/Objectives: The loss of retinal ganglion cells (RGCs) is a hallmark of glaucoma, a major cause of blindness. Glial cell activation due to increased intraocular pressure (IOP) significantly contributes to RGC death.
José A. Matamoros +14 more
doaj +1 more source