Results 71 to 80 of about 3,542,402 (295)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Estudo das proteínas cinases ativadas por mitógenos no desenvolvimento do sistema visual [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Biológicas. Programa de Pós-Graduação em Neurociências.O Sistema Visual representa um excelente modelo para o estudo dos processos plásticos e de desenvolvimento do ...
Oliveira, Camila Salum de
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Ultra-High-Field MRI Morphometry of the Lateral Geniculate Nucleus in Patients with Advanced Visual Loss Due to Late-Stage Retinitis Pigmentosa

Brain Sciences
Background/Objectives: To investigate the volume of the lateral geniculate nucleus (LGN) in patients with advanced retinitis pigmentosa (RP). Methods: Nineteen patients with advanced RP (mean age 52 years and mean duration of illness 357 months) and ...
Katarzyna Nowomiejska, Aleksandra Czarnek-Chudzik, Anna Niedziałek, Robert Rejdak, Radosław Pietura, Kamil Jonak   +5 more
doaj   +1 more source

Ventral Visual Pathway-Cerebellar Circuit Deficits in Alcohol Dependence: Long- and Short-Range Functional Connectivity Density Study

Frontiers in Neurology, 2019
Objective: To identify the underlying intrinsic functional connectome changes in patients with alcohol dependence.Methods: A functional connectivity density (FCD) analysis was used to report on the functional connectivity changes in 24 male patients with
Lingling Chen, Bi-Xia Liu, Run Liu, Jiyong Zheng, Xi-Jian Dai   +4 more
doaj   +1 more source

On the performance of biological movement detectors and ideal velocity sensors in the context of optomotor course stabilization [PDF]

, 1998
Warzecha A-K, Egelhaaf M. On the performance of biological movement detectors and ideal velocity sensors in the context of optomotor course stabilization. Visual Neuroscience.
Egelhaaf, Martin ; https://orcid.org/, ANNE-KATHRIN WARZECHA, MARTIN EGELHAAF, Warzecha, Anne-Kathrin   +3 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Editorial: Application of multimodal imaging combined with artificial intelligence in eye diseases

Frontiers in Neuroscience, 2023
Zhi Wen, Yuchen Chen, Vijaya Prakash Krishnan Muthaiah, Xin Huang   +3 more
doaj   +1 more source

Electrophysiological Study of Visual Pathways in Nevoid Basal Cell Carcinoma Syndrome Patients

Eye and Brain, 2021
Antonietta Moramarco,1,* Ludovico Alisi,1,* Alessandro Lambiase,1 Sandra Giustini,2 Luca Lucchino,1 Emanuele Miraglia,2 Vincenzo Roberti,2 Marcella Nebbioso1 1Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome ...
Moramarco A, Alisi L, Lambiase A, Giustini S, Lucchino L, Miraglia E, Roberti V, Nebbioso M   +7 more
doaj