Results 91 to 100 of about 907,363 (342)

Life in stop motion: a review of akinetopsia

Orphanet Journal of Rare Diseases
Akinetopsia is a rare visual cortical disorder in which patients lose the ability to perceive motion. Visual cortical disorders are often misdiagnosed by most clinicians because they misinterpret the cause of visual dysfunction.
Salma Mowafi, Rana Khashana, May Bakr
doaj   +1 more source

Visual Modeling Languages in Patient Pathways: Scoping Review

Interactive Journal of Medical Research
BackgroundPatient pathways (PPs) are presented as a panacea solution to enhance health system functions. It is a complex concept that needs to be described and communicated well.
Binyam Bogale, Märt Vesinurm, Paul Lillrank, Elisabeth Gulowsen Celius, Ragnhild Halvorsrud   +4 more
doaj   +1 more source

Latency and Selectivity of Single Neurons Indicate Hierarchical Processing in the Human Medial Temporal Lobe [PDF]

, 2008
Neurons in the temporal lobe of both monkeys and humans show selective responses to classes of visual stimuli and even to specific individuals. In this study, we investigate the latency and selectivity of visually responsive neurons recorded from ...
Cerf, Moran, Fried, Itzhak, Koch, Christof, Kornblith, Simon, Kraskov, Alexander, Mormann, Florian, Quian Quiroga, R.   +6 more
core   +1 more source

LGG-37. Long-term Outcome, Visual Morbidity and Prognostic Factors in Infants and Young Children with Optic Pathway Glioma from the Great Ormond Street Hospital (GOSH) LGG - Cohort [PDF]

, 2022
Stefania Picariello, Brownen Walters, Richard Bowman, Olga Slater, Mette Jørgensen, Christine Dahl, Patricia O’Hare, Helen Spoudeas, Hong-Wei Gan, Kristian Aquilina, Yen Ch'in Chang, Felice D’Arco, Darren Hargrave, Enrico Opocher   +13 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Parallel neural pathways in higher visual centers of the Drosophila brain that mediate wavelength-specific behavior

Frontiers in Neural Circuits, 2014
Compared with connections between the retinae and primary visual centers, relatively less is known in both mammals and insects about the functional segregation of neural pathways connecting primary and higher centers of the visual processing cascade ...
Hideo eOtsuna, Kazunori eShinomiya, Kei eIto   +2 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A multi-pathway hypothesis for human visual fear signaling

Frontiers in Systems Neuroscience, 2015
A hypothesis is proposed for five visual fear signaling pathways in humans, based on an analysis of anatomical connectivity from primate studies and human functional connectivity from brain imaging studies.
David N Silverstein, David N Silverstein, Martin eIngvar, Martin eIngvar   +3 more
doaj   +1 more source