Results 81 to 90 of about 3,122,559 (347)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
European Journal of Radiology Open, 2015 Objectives: To qualitatively evaluate late dynamic contrast phases, 10, 20 and 30 min, after administration of Gd-EOB-DTPA with regard to biliary excretion in patients presenting with elevated liver enzymes without clinical signs of cirrhosis or hepatic ...
Bengt Norén +8 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
A visual environment for visual languages
Science of Computer Programming, 2002 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Assessment of Turbulence Models over a Curved Hill Flow with Passive Scalar Transport
Energies, 2022 An incoming canonical spatially developing turbulent boundary layer (SDTBL) over a 2-D curved hill is numerically investigated via the Reynolds-averaged Navier–Stokes (RANS) equations plus two eddy-viscosity models: the K−ω SST (henceforth SST) and the ...
David Paeres +2 more
doaj +1 more source
LMap: Shape-Preserving Local Mappings for Biomedical Visualization
, 2018 Visualization of medical organs and biological structures is a challenging task because of their complex geometry and the resultant occlusions. Global spherical and planar mapping techniques simplify the complex geometry and resolve the occlusions to aid
Gu, Xianfeng +2 more
core +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Scientific ReportsPanoramic radiography is an essential auxiliary diagnostic tool for oral diseases. It is a difficult and time-consuming task to conduct extensive panoramic radiography interpretation. These challenges are exacerbated by the creation of electronic medical
Yue Hong +5 more
doaj +1 more source
APL Materials, 2022 All-inorganic halide semiconductors with perovskite or perovskite-like structure have aroused a widespread concern recently for its environmental friendliness and stabilities while possessing excellent optoelectronic properties.
Mengrou Wang +10 more
doaj +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source