Results 101 to 110 of about 521,031 (345)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Honey bee genotypes and the environment [PDF]
, 2014 Although knowledge about honey bee geographic and genetic diversity has increased tremendously in recent decades (Meixner et al., 2013), the adaptation of honey bees to their local environment has not been well studied.
Buchler, Ralph +7 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Emily Dickinson and the Vitality of Words: A Exercise in Philology [PDF]
, 2017 An article prepared at the request of Kang Yanbin for the Jinan Journal of Foreign ...
Margaret H. Freeman
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Vitality of America's Working Neighborhoods: Meeting the Local Challenges to Multifamily Housing [PDF]
, 2004 On April 24, 2003, Neighborhood Reinvestment hosted the fourth national symposium on multifamily excellence, The Vitality of America's Working Neighborhoods: Meeting the Local Challenges to Multifamily Housing, in Chicago, Illinois.
core
, 2017 Group vitality is a widely invoked construct in the study of minority language maintenance and interethnic relations. Per the original framework introduced 40 years ago, the more vitality an ethnolinguistic group perceives itself to have, the more likely that it will thrive as a collective entity in an intergroup context.
Benjamin King Smith +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Economic vitality in a transition to sustainability [PDF]
The good news is that many of the solutions to this extraordinary problem are within reach. Many of the solutions to global warming are not only feasible, they are economically and socially beneficial. While some claim that addressing global warming will
Goodwin, Neva
core +1 more source