Results 101 to 110 of about 795,329 (311)

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

open access: yesAdvanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo   +17 more
wiley   +1 more source

A Solution‐Based Deposition Method Enabling Pigment Blue Edible Electrochemical Transistors

open access: yesAdvanced Science, EarlyView.
A novel solution‐based method is presented to produce Copper Phthalocyanine fibrous films displaying effective ion permeability and enhanced transconductance in electrolyte‐gated transistors architectures. Using these films, the first instance of a fully edible electrolyte‐gated transistor with volumetric capacitance, targeting in‐body applications, is
Alessandro Luzio   +10 more
wiley   +1 more source

THE ANTINEURITIC VITAMIN

open access: hybrid, 1932
Richard J. Block, George R. Cowgill
openalex   +1 more source

Microporous Polymer Membranes: Molecular Stents Enhanced Solvent‐Accessibility for Organic Solvent Transport

open access: yesAdvanced Science, EarlyView.
A novel microporous polyimide (PI‐TB‐NDI) is designed for enhanced organic solvent nanofiltration. By incorporating o‐methyl groups into the Tröger's base (TB) unit to create molecular stents, the polymer's intrinsic free volume is effectively increased without the need for post‐treatment.
Shuang Guo   +9 more
wiley   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

open access: yesAdvanced Science, EarlyView.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye   +16 more
wiley   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

open access: yesAdvanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang   +9 more
wiley   +1 more source

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