Results 141 to 150 of about 26,277,168 (365)

Frailty and surgical outcomes in gastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients

open access: yesAnnals of Gastroenterological Surgery, Volume 7, Issue 1, Page 27-41, January 2023., 2023
Accumulating evidence demonstrates that the integration of preoperative geriatric assessment and prehabilitation for frail patients into clinical practice may improve perioperative and long‐term outcomes in patients with gastrointestinal cancer. We proposed an example for the integration of older patients‐specific care into treatment strategies for ...
Kosuke Mima   +4 more
wiley   +1 more source

Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury

open access: yesAdvanced Science, EarlyView.
Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang   +12 more
wiley   +1 more source

Perioperative optimization of Crohn's disease

open access: yesAnnals of Gastroenterological Surgery, Volume 7, Issue 1, Page 10-26, January 2023., 2023
Most Crohn's disease patients require surgery during the course of their illness, especially those who experience complications. The management of perioperative medications and surgery‐related decision‐making should be individualized and patient‐centered based on a multidisciplinary approach.
Chun‐Chi Lin   +10 more
wiley   +1 more source

Levels of retinol and retinoic acid in pancreatic cancer, type-2 diabetes and chronic pancreatitis

open access: yesBiomedical Papers
Aims. Retinoids participate in multiple key processes in the human body e.g., vision, cell differentiation and embryonic development. There is growing evidence of the relationship between retinol, its active metabolite- all-trans retinoic acid (ATRA ...
Pavel Hrabak   +10 more
doaj   +1 more source

Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

open access: yesAdvanced Science, EarlyView.
Early detection of hepatocellular carcinoma in patients with liver cirrhosis and/or hepatitis virus B/C infection improves survival. Through marker discovery, 8 methylated DNA markers are identified and a logistic regression model (COMET‐LR) is built in the training set, which achieved 90.0% sensitivity at 97.4% specificity in the validation set.
Tian Yang   +16 more
wiley   +1 more source

Tolerância à aplicação de megadoses de vitamina A associada à vacinação em crianças no Nordeste do Brasil

open access: yesCadernos de Saúde Pública
Um estudo de seguimento foi desenvolvido em duas localidades do semi-árido do estado da Bahia, Nordeste do Brasil, com o objetivo de identificar a ocorrência e a natureza de possíveis efeitos adversos agudos em conseqüência da suplementação com megadoses
Ana Marlúcia Oliveira Assis   +4 more
doaj  

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

open access: yesAdvanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni   +15 more
wiley   +1 more source

Plasma vitamin a and β-carotene levels in pregnant and non-pregnant holstein cows [PDF]

open access: yesEurasian Journal of Veterinary Sciences
This study was carried out to determine the changes of β-carotene and vitamin A levels on pregnant and nonpregnant cows, on 20 primiparous Holstein cows with same management conditions.
Seyfullah Haliloğlu   +3 more
doaj  

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

open access: yesAdvanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong   +20 more
wiley   +1 more source

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