Results 61 to 70 of about 26,277,168 (365)

The stability of 3 transmembrane and 4 transmembrane human vitamin K epoxide reductase models [PDF]

, 2016
3 transmembrane and 4 transmembrane helices models are suggested for the human vitamin K epoxide reductase (VKOR). In this study, we investigate the stability of the human 3 transmembrane/4 transmembrane VKOR models employing a coarse-grained normal mode analysis and molecular dynamics simulation.
arxiv   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Zein/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling

International Journal of Nanomedicine, 2020
Shaimaa Ali Ali Radwan,1 Walaa H El-Maadawy,2 Carol Yousry,1 Aliaa Nabil ElMeshad,1 Raguia Aly Shoukri1 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2Department of Pharmacology, Theodor ...
Radwan SAA, El-Maadawy WH, Yousry C, ElMeshad AN, Shoukri RA   +4 more
doaj  

Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.

New England Journal of Medicine, 2010
BACKGROUND Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease.
A. Sanyal, N. Chalasani, K. Kowdley, A. McCullough, A. Diehl, N. Bass, B. Neuschwander‐Tetri, J. Lavine, J. Tonascia, A. Unalp, M. V. Van Natta, J. Clark, E. Brunt, D. Kleiner, J. Hoofnagle, Patricia R. Robuck   +15 more
semanticscholar   +1 more source

Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results

JAMA Network Open, 2020
Key Points Question Is vitamin D status, reflecting vitamin D levels and treatment, associated with test results for coronavirus disease 2019 (COVID-19)?
D. Meltzer, Thomas J. Best, Hui Zhang, T. Vokes, V. Arora, J. Solway   +5 more
semanticscholar   +1 more source

Bone‐wise rigid registration of femur, tibia, and fibula for the tracking of temporal changes

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Multiple myeloma (MM) induces temporal alterations in bone structure, such as osteolytic bone lesions, which are challenging to identify through manual image interpretation. The large variation in radiologists' assessments, even at expert centers, further complicates diagnosis.
Arttu Ruohola, Ville Haapamäki, Eero Salli, Tuomas Kaseva, Marko Kangasniemi, Sauli Savolainen   +5 more
wiley   +1 more source

Network pharmacology-based approach for exploring the biotargets and mechanisms of vitamin A for the treatment of diabetic foot ulcers

Frigid Zone Medicine, 2023
In some developing countries, people have little knowledge about the causes of diabetic foot ulcers. Therefore, public health education for patients on these conditions is a prerequisite for effective pharmacological treatment. Diabetic foot ulcers are a
Wan Xiaowei, Qin Qiuhai, Xie Ruitang, Li Xin, Su Min   +4 more
doaj   +1 more source

Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.

New England Journal of Medicine, 1992
BACKGROUND The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing such during the periconceptional period.
A. Czeizel, I. Dudás
semanticscholar   +1 more source

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

Vitamin D – The Vitamin Hormone

South African Family Practice, 2016
Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism and seems to have some anti-inflammatory and immune-modulating properties. For most people sunlight is the most important source of vitamin D. The time required to make sufficient vitamin D varies according to a number of environmental, physical and personal factors, but
openaire   +3 more sources