Results 41 to 50 of about 114,972,285 (303)

Prevalence of night blindness in Bashagard district in Hormozgan, Iran, in 2011

Electronic Physician, 2014
Background: Night blindness is a visual disorder associated with unusual vision during the night or in darkness. Vitamin A deficiency (VAD), which is easily preventable, is the main known etiology of night blindness.
Ali Daryanavard, Ebrahim Khajeh, Mahmoud Hosseinpour, Habib Dadvand, Ali Azarpeykan   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prenatal Vitamin D supplementation and child respiratory health: a randomised controlled trial [PDF]

, 2013
Background Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.
Hooper Richard, Richard Hooper, Shaheen Seif O., Warner, JO, Adrian R. Martineau (136644), Poulton, S, Martineau, AR, Goldring, ST, Seif O. Shaheen (177559), Yu, C, Sheree Poulton, Janet Stocks (425915), Christina Yu, Stephen Robinson, Griffiths, CJ, Boyle, RJ, Hooper, R, Kirkby Jane C., Robinson Stephen, Robert J Boyle, Stephen T Goldring, Martineau Adrian R., Warner John O., John O Warner, Goldring Stephen T., Yu Christina, Stocks, J, Chris J. Griffiths (425910), Stocks Janet, Boyle Robert J., Jane C. Kirkby (425914), Janet Stocks, Richard Hooper (425916), Kirkby, JC, Christina Yu (425912), Stephen Robinson (425911), Robinson, S, Shaheen, SO, Jane C Kirkby, Stephen T. Goldring (425909), Poulton Sheree, John O. Warner (425917), Adrian R Martineau, Seif O Shaheen, Robert J. Boyle (425918), Griffiths Chris J., Chris J Griffiths, Sheree Poulton (425913)   +47 more
core   +1 more source

Bilateral Corneal Melting in a Pediatric Patient with Severe Vitamin A Deficiency: A Case Report and Review of Literature

International Medical Case Reports Journal, 2022
Zabih Ur Rahman Roheen, Mirwais Saleh, Tawfiq Ahmad Mushkani Ophthalmology Department, Kabul University of Medical Science, Kabul, AfghanistanCorrespondence: Mirwais Saleh; Tawfiq Ahmad Mushkani, Tel +93786637018 ; +93799123501, Email dr.mirwaissaleh465 ...
Roheen ZUR, Saleh M, Mushkani TA
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin B12 status in older adults; secondary outcome analysis from the CENEX Study (ISRCTN48153354). [PDF]

, 2013
BACKGROUND: Older people are at increased risk of vitamin B12 deficiency and the provision of fortified foods may be an effective way to ensure good vitamin B12 status in later life.
Sánchez Reyes, Hugo, Albala Brevis, Cecilia, Uauy, Ricardo, Alan D Dangour, Cecilia Albala, Lera, Lydia, Hugo Sanchez, Sanchez, Hugo, Lydia Lera, Uauy Dagach-Imbarack, Ricardo, Dangour, Alan D., Lera Marques, Lydia, Dangour, Alan D, Ricardo Uauy, Hugo HugoSanchez, Albala, Cecilia   +15 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source