Results 51 to 60 of about 114,972,285 (303)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Vitamin D, innate immunity and outcomes in community acquired pneumonia [PDF]

, 2011
We investigated the associations between vitamin D status, the antimicrobial peptides cathelicidin and beta defensin-2 and outcomes in community acquired pneumonia.
Karalus, Noel, LEONG LEOW, Cursons, Raymond T., RAY CURSONS, Hancox, Robert J., Leow, Leong, NOEL KARALUS, ROBERT J. HANCOX, TALIA SIMPSON, Leong, Talia   +9 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Proceedings of the Rank Forum on Vitamin D [PDF]

, 2010
The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and ...
Lamberg-Allardt, C, C. Nowson, Martineau, A.R., Miles, LM, Lamberg-Allardt, C., Martineau, AR, Darling, A. L., Macdonald, H M, H. M. Macdonald, Berry, J.L., A. L. Darling, Fraser, WD, S. Reddy, M. Kiely, Darling, A.L., de Groot, CPGM, Macdonald, H. M., C. P. G. M. de Groot, S. A. Lanham-New, Prentice, A., Mavroeidi, A.; id_orcid, de Groot, C P G M, Kiely, M., Stone, E M, Fraser, W. D., Miles, L.M., Macdonald, HM, Lanham-New, S. A., Masud, T, De Groot, C. P.G.M., A. Prentice, Francis, R.M., Vieth, R, Francis, RM, K. D. Cashman, Masud, T., E. Hyppönen, Williams, C. M., Boucher, BJ, de Groot, C.P.G.M., Williams, Christine Mary, Mavroeidi, A., Buttriss, J L, de Groot, C. P. G. M., Boucher, B.J., Mavroeidi, A, Reddy, S., A. Mavroeidi, Nowson, C., Stone, E.M., Cooper, C., W. D. Fraser, Fraser, W D, Cooper, C, A. R. Martineau, Boucher, B. J., Berry, J L, E. M. Stone, Buttriss, J.L., C. Cooper, Francis, R. M., Stone, EM, Williams, CM, Reddy, S, Kiely, K, Kiely, M, Hyppönen, E, T. Masud, Martineau, A. R., Francis, R M, Lanham-New, SA, Vieth, R., C. M. Williams, Hyppönen, E., Prentice, A, Macdonald, H.M., B. J. Boucher, M. Ashwell, Williams, M., J. L. Berry, Ashwell, M., Buttriss, JL, Fraser, W.D., L. M. Miles, Miles, L. M., Nowson, C, Stone, E. M., Cashman, K.D., Lanham-New, S A, C. Lamberg-Allardt, Cashman, K D, Berry, J. L., Berry, J.L, Miles, L M, Cashman, K. D., Ashwell, M, Darling, A L, Buttriss, J. L., J. L. Buttriss, Cashman, KD, de Groot, C.P., R. Vieth, Darling, AL, Williams, C.M., Berry, JL, Lanham-New, S.A., Boucher, B J, Groot, C.P.G.M., de, R. M. Francis, Williams, C M, Martineau, A R, Hypöpnen, E., Hyppöpnen, E., Lanham New, S.A.   +113 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Prevalence of vitamin B12 insufficiency during pregnancy and its effect on offspring birthweight: a systematic review and meta-analysis. [PDF]

, 2016
Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis. Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India, and although this has been linked to low birth weight (LBW) in these ...
Rafnsson, Snorri B., Kandala, Ngianga-Bakwin, Saravanan, Ponnusamy, Yajnik, Chittaranjan, Sukumar, Nithya, Rafnsson, Snorri B, Bhopal, Raj, Yajnik, Chittaranjan S., Rafnsson, Snorri, Yajnik, Chittaranjan S   +9 more
core   +1 more source