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Interpretable Machine Learning to Predict Metformin-Induced Vitamin B12 Deficiency: Association with Glycemic Control and Neuropathic Symptoms. [PDF]
MetabolitesSalhi Y +6 more
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2022
Photoreceptor proteins enable living organisms to sense light and transduce this signal into biochemical outputs to elicit appropriate cellular responses. Their light sensing is typically mediated by covalently or noncovalently bound molecules called chromophores, which absorb light of specific wavelengths and modulate protein structure and biological ...
S, Padmanabhan +4 more
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Photoreceptor proteins enable living organisms to sense light and transduce this signal into biochemical outputs to elicit appropriate cellular responses. Their light sensing is typically mediated by covalently or noncovalently bound molecules called chromophores, which absorb light of specific wavelengths and modulate protein structure and biological ...
S, Padmanabhan +4 more
openaire +2 more sources
Nature Reviews Disease Primers, 2017
Vitamin B12 (B12; also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. Clinical B12 deficiency with classic haematological and neurological manifestations is relatively uncommon.
Green, Ralph +11 more
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Vitamin B12 (B12; also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. Clinical B12 deficiency with classic haematological and neurological manifestations is relatively uncommon.
Green, Ralph +11 more
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1957
Publisher Summary Since the chemistry of the antipernicious anemia factor, vitamin B 12 , was last reviewed in “Vitamins and Hormones” by Folkers and Wolf, outstanding progress has been made, resulting in the complete structural elucidation of the vitamin.
A W, JOHNSON, A, TODD
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Publisher Summary Since the chemistry of the antipernicious anemia factor, vitamin B 12 , was last reviewed in “Vitamins and Hormones” by Folkers and Wolf, outstanding progress has been made, resulting in the complete structural elucidation of the vitamin.
A W, JOHNSON, A, TODD
openaire +2 more sources
2022
Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons.
Ralph, Green, Joshua W, Miller
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Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons.
Ralph, Green, Joshua W, Miller
openaire +2 more sources
Journal of the American Pharmaceutical Association (Scientific ed.), 1956
Abstract The rate of destruction of crystalline vitamin Bu in neutral aqueous solutions, when exposed to direct sunlight, indirect sunlight, dim daylight, artificial light, ultraviolet light, and various monochromatic light sources has been determined.
L J, DEMERRE, C, WILSON
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Abstract The rate of destruction of crystalline vitamin Bu in neutral aqueous solutions, when exposed to direct sunlight, indirect sunlight, dim daylight, artificial light, ultraviolet light, and various monochromatic light sources has been determined.
L J, DEMERRE, C, WILSON
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BMJ, 2014
#### Summary points Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences.1 Intracellular conversion of vitamin B12 to two active coenzymes ...
Alesia, Hunt +2 more
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#### Summary points Vitamin B12 is an essential cofactor that is integral to methylation processes important in reactions related to DNA and cell metabolism, thus a deficiency may lead to disruption of DNA and cell metabolism and thus have serious clinical consequences.1 Intracellular conversion of vitamin B12 to two active coenzymes ...
Alesia, Hunt +2 more
openaire +2 more sources