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Vitamin B12 deficiency

open access: yesNature Reviews Disease Primers, 2017
Vitamin B12 (B12; also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. Clinical B12 deficiency with classic haematological and neurological manifestations is relatively uncommon.
Green, Ralph   +11 more
openaire   +5 more sources
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Metformin‐induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes

Diabetes, obesity and metabolism, 2022
Metformin blocks the absorption of vitamin B12 through a mechanism that has not been established but could be because of interference with the calcium‐dependent binding of the intrinsic factor vitamin B12 complex to the cubam receptor in the terminal ...
D. Bell
semanticscholar   +1 more source

Effects of Folic Acid and Vitamin B12 Supplementation on Cognitive Impairment and Inflammation in Patients with Alzheimer's Disease: A Randomized, Single-Blinded, Placebo-Controlled Trial

The journal of prevention of Alzheimer's disease, 2021
To evaluate the combined action of folic acid and vitamin B12 supplementation on cognitive performance and inflammation in patients with Alzheimer’s disease (AD). This was a randomized, single-blind, placebo-controlled trial.
H. Chen   +9 more
semanticscholar   +1 more source

Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis.

Nutrition reviews, 2021
CONTEXT The results from epidemiologic studies on the intake of dietary vitamin B1, B2, B6, and B12 and association with risk of developing depression have been inconsistent.
Yanjun Wu   +3 more
semanticscholar   +1 more source

The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents.

Child and Adolescent Mental Health, 2020
BACKGROUND Depression is a heterogeneous disorder and is thought to develop as a result of complex interactions between genetic and environmental factors. One-carbon metabolism that includes vitamin B12, folic acid, and homocysteine has been investigated
E. Esnafoglu, Deniz Deniz Ozturan
semanticscholar   +1 more source

Vitamin B12

Biochimica et Biophysica Acta, 1950
Abstract 1. 1. In mildly acid solutions, kept in the dark, the spectrum of vitamin B 12 remains unchanged; on exposure to light, vitamin B 12b is rapidly formed. 2. 2. The spectrum of an irradiated solution ( pH ≧ 4 ), subsequently kept in the dark, shows a slow reversal to that of vitamin B 12 . 3. 3.
W. L. C. Veer   +3 more
openaire   +3 more sources

Vitamin B12 photoreceptors

2022
Photoreceptor proteins enable living organisms to sense light and transduce this signal into biochemical outputs to elicit appropriate cellular responses. Their light sensing is typically mediated by covalently or noncovalently bound molecules called chromophores, which absorb light of specific wavelengths and modulate protein structure and biological ...
Padmanabhan, Subramanian   +4 more
openaire   +3 more sources

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