Results 161 to 170 of about 79,292,901 (294)
Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics
Advanced Science, EarlyView.Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan +5 more
wiley +1 more source
AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells
Advanced Science, EarlyView.Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding +12 more
wiley +1 more source
Selenite cataract and its attenuation by vitamin E in wistar rats.
Indian Journal of Ophthalmology, 2003 Purpose: To study the role of vitamin E in preventing cataract formation in experimental animals. Methods: An experimental model (selenite cataract) was selected for this study. Selenite cataract was produced in rats by subcutaneous administration of
Mathew Joe, Thomas V, Thomas Issac
doaj
Anemia and Vitamin B-12 and Folate Status in Women of Reproductive Age in Southern India: Estimating Population-Based Risk of Neural Tube Defects. [PDF]
Curr Dev Nutr, 2021 Finkelstein JL +12 more
europepmc +1 more source
Advanced Science, EarlyView.Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li +9 more
wiley +1 more source
Advanced Science, EarlyView.A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu +13 more
wiley +1 more source
Vitamin B-12 and neuropathy in the elderly [PDF]
The American Journal of Clinical Nutrition, 2016 openaire +2 more sources
The Potential of Self‐Maintainable Living Materials
Advanced Science, EarlyView.Self‐maintainable living materials are presented as the next generation of bioadaptive systems, integrating continuous sensing, decision‐making, response, self‐repair, and adaptation in a closed‐loop framework. This review highlights the design principles and emerging technologies that enable autonomous, long‐term functionality for future regenerative ...
Mohammadsadegh Nadimifar +4 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang +10 more
wiley +1 more source
The acute presentation of nitrous oxide-induced vitamin B-12 deficiency in a postoperative lumbar discectomy patient: illustrative case. [PDF]
J Neurosurg Case LessonsAcharya A, Fossett D.
europepmc +1 more source