Results 51 to 60 of about 863,295 (352)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Vitamin B₁₂ deficiency and Parkinson’s disease

Неврология, нейропсихиатрия, психосоматика, 2023
Parkinson’s disease (PD) is a progressive neurodegenerative disease with various clinical manifestations, its origin not always can be explained only by dopamine deficiency. Long-term treatment with levodopa (especially its intraduodenal administration),
Z. A. Zalyalova, E. V. Ekusheva
doaj   +1 more source

Comparative effectiveness of B and E vitamins with diclofenac in reducing pain due to osteoarthritis of the knee [PDF]

, 2015
Background: Knee osteoarthritis is one of the most prevalent chronic disorders. Several pharmacological and non pharmacological approaches are used to treat this disease. Today, the effect of B and E vitamins on rheumatology diseases is being discussed.
Dehghan, M.
core   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Pengaruh Vitamin B1, B6 dan B12 terhadap Intensitas Nyeri Pasca Seksio Sesarea

Jurnal Anestesi Obstetri Indonesia
Latar Belakang: Seksio sesarea (SC) digunakan sebagai solusi ketika persalinan normal tidak memungkinkan karena alasan medis tertentu. Beban global pemulihan bedah obstetri mencakup sekitar 140.000.000 kelahiran setiap tahun dengan perkiraan tingkat ...
Felicia Tarang, Muhammad Ramli Ahmad, Madonna D. Datu, Syafri Kamsul Arif, Alamsyah Ambo Ala Husain, Muhammad Rum   +5 more
doaj   +1 more source

Hampered Vitamin B12 Metabolism in Gaucher Disease?

Journal of Inborn Errors of Metabolism and Screening, 2017
Untreated vitamin B 12 deficiency manifests clinically with hematological abnormalities and combined degeneration of the spinal cord and polyneuropathy and biochemically with elevated homocysteine (Hcy) and methylmalonic acid (MMA).
Luciana Hannibal PhD, Marina Siebert PhD, Suélen Basgalupp MSc, Filippo Vario MD, PhD, Ute Spiekerkoetter MD, Henk J. Blom PhD   +5 more
doaj   +1 more source

Decreased vitamin B 12 and folic acid concentrations in acne patients after isotretinoin therapy: A controlled study

Indian Journal of Dermatology, 2014
Background: Oral isotretinoin treatment might influence the levels of vitamin B 12 and folic acid. Aims and Objectives: The aim of this study is to compare vitamin B 12 and folic acid levels in patients with moderate and severe acne vulgaris with those ...
Hilal Gökalp, I Bulur, M A Gürer
doaj   +1 more source

Vitamin D related genes in lung development and asthma pathogenesis [PDF]

, 2014
Background: Poor maternal vitamin D intake is a risk factor for subsequent childhood asthma, suggesting that in utero changes related to vitamin D responsive genes might play a crucial role in later disease susceptibility.
Anderson, Chris, Gaedigk, Roger, Kho, Alvin T, Klanderman, Barbara, Leeder, James S, Niu, Simin, Qiu, Weiliang, Sharma, Sunita, Tantisira, Kelan G, Weiss, Scott T   +9 more
core   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Cellular Import of Cobalamin (Vitamin B-12) [PDF]

The Journal of Nutrition, 1999
Recent studies have isolated and characterized human gastric intrinsic factor (IF) and transcobalamin II (TC II) genes, whose products mediate the import of cobalamin (Cbl; Vitamin B-12) across cellular plasma membranes. Analyses of cDNA and genomic clones of IF and TC II have provided some important insights into their sites of expression, structure ...
Bellur Seetharam, Ning Li, Santanu Bose
openaire   +3 more sources