Results 211 to 220 of about 362,924 (333)

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Nutritional myopathy associated with selenium and copper deficiency in beef cattle in Argentina. [PDF]

J Vet Diagn Invest
Castro DJ, Margineda CA, Mattioli GA, Poppenga R, Uzal FA.   +4 more
europepmc   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Maternal First-Trimester Vitamin B12 Levels as a Determinant of Infant Deficiency: A Single-Center Retrospective Study. [PDF]

Cureus
Ata S, Tas I.
europepmc   +1 more source

Vitamin B-6 Deficiency Alters Rat Enterocyte Calcium Homeostasis but Not Duodenal Transport

, 1993
M. Matyaszczyk, Elżbieta Karczmarewicz, E. Czarnowska, Robert D. Reynolds, R Lorenc   +4 more
openalex   +1 more source

Effects of vitamin B-6 deficiency on selenium metabolism in the rat.

Journal of NutriLife, 1989
M. A. Beilstein, P. Whanger
semanticscholar   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Vitamin D Supplementation in Orthopedic Trauma: Influence on Immune Modulation, Fracture Healing, and Infection Outcomes. [PDF]

Cureus
Jha G, Dhanjal R, Hamza A.
europepmc   +1 more source

Biochemical evidence for a deficiency of vitamin B ₆ in the carpal tunnel syndrome based on a crossover clinical study

, 1978
Karl Folkers, John M. Ellis, Tatsuo Watanabe, Seisuke SAJI, Masahiro Kaji   +4 more
openalex   +2 more sources

Enhanced Recognition via Defect Engineered Amorphous Metal–Organic Framework for Sensitive and Stable Pesticide Biosensor

Advanced Science, EarlyView.
A defect‐engineered assembly strategy is reported for the in situ encapsulation of acetylcholinesterase (AChE) into amorphous MOF‐74, endowing the composite with superior catalytic activity and target recognition capability. Leveraging these structural advantages, a sensitive and stable biosensor is constructed for the detection of paraoxon pesticide ...
Changshun Su, Xiangyu Zhai, Meng Zhang, Mengxue Li, Xinru Zhang, Chunyan Sun, Xu Yan, Hongxia Li   +7 more
wiley   +1 more source