Results 51 to 60 of about 92,834,848 (305)

Calcium deficiency in children: causes, effects, and opportunities for preventive interventions [PDF]

РМЖ. Мать и дитя, 2023
E.A. Samorodnova Kazan State Medical University, Kazan, Russian Federation Calcium deficiency is a commonly occurring condition in children of different age groups, primarily due to the inadequate calcium intake with food, high ...
E.A. Samorodnova
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin d in mice fed a high-fat diet [PDF]

, 2014
The role of vitamin D in curtailing the development of obesity and comorbidities such as the metabolic syndrome (MetS) and type 2 diabetes has received much attention recently. However, clinical trials have failed to conclusively demonstrate the benefits
Feelisch, Martin, Weller, Richard B; id_orcid, Matthews, Vance, Jacoby, Peter, Endersby, Raelene, Hart, Prue H, Geldenhuys, Sian, Weller, Richard B., Hart, Prue H., Gorman, Shelley   +9 more
core   +1 more source

Causal relationships of familial hypercholesterolemia with the risk of multiple vitamin deficiencies: a Mendelian randomization study

Frontiers in Endocrinology
BackgroundThe causal relationship between familial hypercholesterolemia (FH) and various vitamin deficiencies has not yet been elucidated. Therefore, this study investigated the cause-and-effect relationship between FH and the risk of multiple vitamin ...
Cheng Zhang, Gang Wei, Huan Zhou, Lin Liu   +3 more
doaj   +1 more source

Relationship between inflammatory biomarkers, vitamin D levels, and depressive symptoms in late pregnancy and during the postpartum period: a prospective, observational study

Middle East Current Psychiatry, 2022
Background Perinatal depression impacts maternal and fetal health, and exhibits a high rate of continuity postpartum. Not only does it impair the maternal quality of life, it also increases the risk of adverse birth and developmental problems in ...
Ola Ali Nassr, Mohammed Mahmood Mohammed, Hind Abdulkhaliq Showman   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Micronutrient malnutrition and wasting in adults with pulmonary tuberculosis with and without HIV co-infection in Malawi. [PDF]

, 2004
BACKGROUND: Wasting and micronutrient malnutrition have not been well characterized in adults with pulmonary tuberculosis. We hypothesized that micronutrient malnutrition is associated with wasting and higher plasma human immunodeficiency virus (HIV ...
Johnny J Kumwenda, Tamara D Clark, Richard D Semba, Harries Anthony D, Zijlstra, Ed E, Clark Tamara D, Taha Taha E, Taha, Taha E, Kumwenda, Johnny J, Semba Richard D, Anthony D Harries, Kumwenda Johnny J, Zijlstra Ed E, Harries, Anthony D, Monique van Lettow, Taha E Taha, Clark, Tamara D, van Lettow Monique, van Lettow, Monique, Ed E Zijlstra, Semba, Richard D   +20 more
core   +2 more sources

Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease

Frontiers in Nutrition, 2021
Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a variant (rs344) in the HBB gene encoding the β-globin subunit of hemoglobin. Chronic hemolytic anemia and increased erythropoiesis and RBC turnover in individuals with SCD can result ...
Brock A. Williams, Brock A. Williams, Cara Mayer, Cara Mayer, Heather McCartney, Angela M. Devlin, Angela M. Devlin, Yvonne Lamers, Yvonne Lamers, Suzanne M. Vercauteren, Suzanne M. Vercauteren, John K. Wu, John K. Wu, Crystal D. Karakochuk, Crystal D. Karakochuk   +14 more
doaj   +1 more source

Functional and Metabolic Consequences of Vitamin B-6 Deficiency in the Rat Heart

Experimental Biology and Medicine, 1987
The cardiac functional and metabolic consequences of pyridoxine deficiency were studied in rats maintained on a pyridoxine-deficient diet for 10 weeks. Because food intake was diminished in the pyridoxine-deficient rats, a second group of animals was fed a diet restricted to the intake of the pyridoxine-deficient animals.
Feldman, Arthur M., Guilarte, Tomas R., Baughman, Kenneth L., Gerstenblith, Gary   +3 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source