Results 101 to 110 of about 19,174,629 (255)

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Vitamin C and Somatic Cell Reprogramming

, 2020
Vitamin C plays a pivotal role in somatic cell reprogramming by enhancing the activity of numerous epigenetic regulators belonging to a broad family of Fe2+ and α-ketoglutarate-dependent dioxygenases (α-KGDDs).
Cimmino, Luisa, Luisa Cimmino, Jingjing Wang, Wang, Jingjing   +3 more
core   +1 more source

Vitamin D deficiency and posterior subcapsular cataract [PDF]

, 2015
Craig J Brown,1 Faical Akaichi21The Eye Center, Fayetteville, AR, USA; 2Scotland’s Rural College, Edinburgh, UKPurpose: To evaluate risk factors associated with posterior subcapsular cataract (PSC) development and the relationship between vitamin D
Brown, CJ, Akaichi F, Akaichi, F; id_orcid, Brown CJ   +3 more
core   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Purpuric rash after starting hemodialysis—not the immediate suspect: a case report and literature review

Frontiers in Nephrology
BackgroundVitamin C deficiency is an underrecognized yet prevalent concern in hemodialysis patients, driven by dietary restrictions, increased oxidative stress, and vitamin losses during dialysis.
George Jiries, George Jiries, Olga Vdovich, Olga Vdovich, Ashraf Badran, Etty Kruzel-Davila, Etty Kruzel-Davila   +6 more
doaj   +1 more source

Vitamin D Deficiency in Adults with Musculoskeletal Pain

, 2015
Objective: The aim of this study was to determine whether vitamin D deficiency in patients with musculoskeletal pain who were admitted to our hospital and to establish the difference between vitamin D levels according to gender and age groups ...
Roni Atalay, Sevgi Gümüş Atalay, Sinem Bozkurt, Özge Ardıçoğlu, Fatma Fidan, Berat Meryem Alkan, Hatice Aksekili   +6 more
core   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Vitamin D effects on Chlamydia trachomatis infection: a case-control and experimental study

Frontiers in Cellular and Infection Microbiology
IntroductionVitamin D deficiency is the most common nutritional deficiency worldwide. Chronic vitamin D deficiency causes immune system dysfunction, which increases susceptibility to pathogens such as bacteria, especially intracellular parasites, and ...
Sijia Liu, Tianwei Zhao, Quanzhong Liu
doaj   +1 more source

Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens : a one-year prospective study [PDF]

, 2013
Background Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objective of this study was to determine
Majed S Alokail, Al-Othman, Abdulaziz, Osama Moharram, Yousef Al-Saleh, Shaun B Sabico, Chrousos, George P., Kumar, Sudhesh, Sabico, Shaun, Abdulaziz Al-Othman, Nasser M Al-Daghri, Sudhesh Kumar, George P Chrousos, Alokail, Majed S., Al-Daghri, Nasser M., Al-Saleh, Yousef, Moharram, Osama, Alkharfy, Khalid M., Khalid M Alkharfy   +17 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source