Results 121 to 130 of about 19,174,629 (255)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Scurvy as a mimicker of arthritis: Isolated hemarthrosis due to vitamin C deficiency, a case report
Journal of Orthopaedic ReportsScurvy, linked to Vitamin C deficiency, can be challenging to diagnose in the western hemisphere, known for its ample Vitamin C-rich dietary choices. Moreover, presentation of the symptoms may vary and lead to a complex, diagnostic dilemma.
Rohit Sharma +2 more
doaj +1 more source
Advanced Science, EarlyView.This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu +10 more
wiley +1 more source
Advanced Science, EarlyView.A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal +5 more
wiley +1 more source
Vitamin C Deficiency With Oral Lesions As Initial Symptom
International Dental JournalIntroduction: This case report describes a 24-year-old man with a complaint of gingival hyperplasia in oral medicine department. He was eventually diagnosed with vitamin C deficiency according to his presentation, eating habit and the successful ...
Feiran Lin, Xiaobing Guan
doaj +1 more source
Evaluation of Association of Vitamin D Deficiency with Depression in Postmenopausal Women
, 2015 Objective: This study was aimed to investigate the association of depression with vitamin D deficiency in postmenopausal women. Materials and Methods: Postmenopausal women over 55 years who were independent in personal care and who could live ...
Gül Mete Civelek
core +1 more source
Advanced Science, EarlyView.Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li +23 more
wiley +1 more source
BMC NutritionPurpose Vitamin C is a fundamental antioxidant with important metabolic actions in several biological processes. Patients with type 2 diabetes (T2D) are exposed to oxidative stress as a consequence of an increased production of reactive oxygen species ...
Anna Toffalini +6 more
doaj +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source