Vitamin D sensitivity to the immune responses and autoimmunity: A chemical network model study [PDF]
Although Vitamin D is believed to be involved in a large number of immune responses our understanding of these processes at cellular level remained at infancy. We develop and solve a coarse grained kinetic network model to quantify the effects of variation of vitamin D on human immunity. The system of equations accounts for known inter-relation between
arxiv
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo+11 more
wiley +1 more source
An investigation of vitamin D metabolism in kiwi (Apteryx mantelli), tuatara (Sphenodon punctatus) and New Zealand sea lion (Phocarctos hookeri) and the relationship of vitamin D metabolism with their life history characteristics : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Studies at Massey University, Turitea, Palmerston North, New Zealand [PDF]
Vitamin D, a fat-soluble vitamin, has a wide range of functions in vertebrates. The aim of the study was to determine if the evolutionary history of different animal species affects their predominant route of vitamin D metabolism.
Kale, Madhumita Sanjay
core
Calculation of the Sun exposure time for the synthesis of vitamin D in Urcuquí, Ecuador [PDF]
The synthesis of vitamin D is strongly linked to the availability of solar energy. For a long time, it was clear that using the erythemal irradiances is a good choice to calculate the exposure time. Several authors argue that this method of minimum exposure time overestimates the calculation of the solar irradiance of vitamin D.
arxiv
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto+2 more
wiley +1 more source
Global vitamin D status problems: causes, pathogenetic mechanisms, treatment, prevention measures
There is a need to improve the status of vitamin D. Vitamin D not only affects the processes of formation of the musculoskeletal system, but also actively participates in many extra-osseous effects of cholecalciferol.
N. A. Buralkina+2 more
doaj +1 more source
Comparative analysis of vitamin D content in sardines canned in olive oil and water [PDF]
Vitamin D is a fat-soluble hormone primarily responsible in maintaining plasma calcium and phosphorus homeostasis in humans. Vitamin D insufficiency and deficiency is a global health issue.
Kalajian, Tyler Arek
core +1 more source
Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface [PDF]
Plasma concentrations of biologically active vitamin D (1,25- (OH)2D) are tightly controlled via feedback regulation of renal 1-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes.
Albertson+101 more
core +3 more sources
A repeated measures approach to pooled and calibrated biomarker data [PDF]
Participant level meta-analysis across multiple studies increases the sample size for pooled analyses, thereby improving precision in effect estimates and enabling subgroup analyses. For analyses involving biomarker measurements as an exposure of interest, investigators must first calibrate the data to address measurement variability arising from usage
arxiv
This proof‐of‐concept study involves high‐throughput teratogenicity screening of compounds using XEn/EpiCs, a 3D stem cell‐based embryo model, within microwells. The term ‘morphotoxicity’ is introduced to complement traditional cytotoxicity assays through automated feature extraction and machine‐learning‐assisted classification of morphologies.
Vinidhra Shankar+4 more
wiley +1 more source