Results 111 to 120 of about 794,897 (330)

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielman, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Prescription analgesic overuse in older adults: Can we mitigate this growing problem?

AGING MEDICINE, Volume 5, Issue 4, Page 294-296, December 2022., 2022
With older adults already on numerous prescription medications to manage their chronic conditions, the addition of pain medications could impose an even greater burden due to dependency issues. We need to understand the use of chronic pain medication, especially opioids, discuss current strategies and gaps, and offer potential solutions to mitigate ...
Sara Kakatkar, Aditya Narayan, Rajesh Balkrishnan   +2 more
wiley   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Improving osteoporosis treatment rates in inpatients admitted with hip fracture: A healthcare improvement initiative in a tertiary referral hospital

AGING MEDICINE, Volume 5, Issue 4, Page 264-271, December 2022., 2022
Our hospital introduced a standardized protocol for the treatment of osteoporosis in patients admitted for hip fracture. The aim of this article was to describe its implementation as well as assess the protocol's effect on treatment rates and safety. In our analysis, there was significant improvement in treatment rates with no instances of acute kidney
Andrew Gan Lin, Nargis Shaheen, Kirtan Ganda, John Cullen, Louise M. Waite, Markus J. Seibel   +5 more
wiley   +1 more source

The vitamin D content of tissues of rats given ergocalciferol [PDF]

, 1954
E. M. Cruickshank, E. Kodíček, P. Armitage   +2 more
openalex   +1 more source

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source

Osteal and extraosteal effects of vitamin D and its opportunities of medication correction of its deficiency

Медицинский совет, 2018
A well-known crucial role of Vitamin D is in the maintenance of musculoskeletal system. In terms of high prevalence of violations of calcium-phosphorus metabolism, in the following article we will touch upon some aspects bone metabolic dysfunction ...
V. V. Salukhov, E. A. Kovalevskaya, V. V. Kurbanova   +2 more
doaj   +1 more source

Optimization of brain and life performance: Striving for playing at the top for the long run [PDF]

German version published as: "Du kannst dein Leben steigern'', in: Schweizer Monat, Dezember 2011/Januar 2012, 38-49, 2011
In this essay written with my students and collaborators in mind, I share simple recipes that are easy and often fun to put in practice and that make a big difference in one's life. The seven guiding principles are: (1) sleep, (2) love and sex, (3) deep breathing and daily exercises, (4) water and chewing, (5) fruits, unrefined products, food ...
arxiv  

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

Advanced Science, EarlyView.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp, Ryun Hee Kim, Adithyan Jayaraman, Nils Klement, Raymond Kostlan, Chang H. Kim   +5 more
wiley   +1 more source

Correlation of multiple sclerosis incidence in the UK 1990-2010 with geomagnetic disturbances [PDF]

arXiv, 2013
Recently, Mackenzie et al. reported incidence and prevalence of multiple sclerosis (MS) in the UK from 1990-2010. Authors of this report indicated that they could not explain the cause of decreasing MS incidence trend in the UK during this time period.
arxiv