Results 151 to 160 of about 149,521 (328)

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu, Long‐Lan Shu, Tao Lu, Da‐Yu Guan, Bo‐Wen Zheng, Pan‐Hui Xiong, Yang Shen, Yu‐Cheng Yang   +7 more
wiley   +1 more source

Origin of phase relative stability and phase transformation in an S‐ibuprofen–nicotinamide cocrystal

Acta Crystallographica Section C, EarlyView.
The crystal structure of the metastable form of S‐ibuprofen–nicotinamide cocrystals was solved from powder X‐ray diffraction data and explains the main mechanisms responsible for the relative stability of the two forms of the cocrystals. This also made it possible to explain the transition mechanism between the two forms with temperature.The crystal ...
Mathieu Guerain, Hubert Chevreau, Erik Elkaim, Yannick Guinet, Laurent Paccou, Florence Danède, Alain Hedoux, Frederic Affouard   +7 more
wiley   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Anti‐IL‐5 Vaccination Dampens Allergen‐Specific IgE Levels and Modulates IL‐4 and IL‐5 Th2 Cytokines in Skin Allergy of Mice and Horses

Allergy, EarlyView.
This study investigates the effect of IL‐5 vaccination on allergen‐specific IgE levels, as well as mRNA and protein expression of Th1/Th2‐associated cytokines using a murine OVA skin allergy model and the naturally occurring skin allergy IBH in horses.
Fadi Jebbawi, Florian Olomski, Victoria Inversini, Giulia Keller, Tanya Rhiner, Nina Waldern, Juwela Lam, Stanislav Pantelyushin, Fabia Canonica, Katharina Birkmann, Pål Johansen, Thomas M. Kündig, Antonia Fettelschoss‐Gabriel   +12 more
wiley   +1 more source

THE SPECTROPHOTOMETRIC DETERMINATION OF VITAMINS D2 AND D3

, 1940
Cyril H. Nield, Walter C. Russell, A. Zimmerli   +2 more
openalex   +1 more source

1,25-Dihydroxyvitamin D3 and 1,α-Hydroxyvitamin D3 in Children: Biologic and Therapeutic Effects in Nutritional Rickets and Different Types of Vitamin D Resistance [PDF]

, 1975
S Balsan, M Garabédian, R. Sorgniard, Michael F. Holick, Hector F. DeLuca   +4 more
openalex   +1 more source

Microenvironment‐Driven Mast Cell Plasticity: Insights From Cytokine‐Activated Gene Signatures in Skin and Respiratory Diseases

Allergy, EarlyView.
Primary peripheral blood‐derived human mast cells exposed to IFNγ, IL‐33, IL‐4 + IL‐13, or TGFβ develop distinct transcriptional signatures with unique functional changes including degranulation and cytokine/chemokine release. Machine learning‐defined minimal cytokine‐activated signatures (245 genes) successfully detect cytokine‐primed mast cells in ...
Chiara Tontini, Rajia Bahri, Andrew Higham, Dave Singh, Angela Simpson, Silvia Bulfone‐Paus   +5 more
wiley   +1 more source

Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice

Allergy, EarlyView.
Diet‐induced obesity increases transepidermal water loss and compromises barrier function through downregulation of tight junctions and desmosomes. During obesity, MC903 elicits a mixed Th1/2/17 immune response in the skin leading to aggravated ear swelling.
Alicia Martinek, Andrea Deinzer, Roman G. Gerlach, Jana Petzold, Lea Semmler, Christof Vorsatz, Padraic G. Fallon, Christian Schwartz   +7 more
wiley   +1 more source

PROGRESS OF HYPERVITAMINOSES D2 AND D3 AND RECOVERY IN RATS, AS AFFECTED BY DIETARY CALCIUM AND PHOSPHORUS AND VITAMIN A

, 1940
Agnes Fay Morgan, Nobuko Shimotori, Jeannette B. Hendricks   +2 more
openalex   +1 more source

Basophils in Skin‐Mediated Sensitization Drive Subsequent Lung Inflammation in Airway‐Challenged Mice

Allergy, EarlyView.
In an atopic dermatitis model, basophils promote inflammation, barrier disruption, and IgE production to skin‐encountered OVA. Basophils drive allergic sensitization via the skin, predisposing lungs to inflammation upon airway challenge with the same allergen.
E Da Choi, David Voehringer, Daniel Radtke   +2 more
wiley   +1 more source