Results 211 to 220 of about 174,577 (254)
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Vitamin D and the vitamin D receptor in liver pathophysiology
Clinics and Research in Hepatology and Gastroenterology, 2011Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis on the liver remains to be evaluated. In this review, we will describe vitamin D metabolism and the mechanisms of homeostatic control.
Zúñiga, Silvia +3 more
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Vitamin D receptor and analogs
Seminars in Nephrology, 2004In chronic kidney disease (CKD), high circulating levels of parathyroid hormone (PTH) cause osteitis fibrosa, bone loss, and cardiovascular complications that increase morbidity and mortality. Impaired production of 1,25-dihydroxyvitamin D (calcitriol), the hormonal form of vitamin D, is a major contributor to the generation and maintenance of ...
Adriana S, Dusso +2 more
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The International Journal of Artificial Organs, 2009
The fields for clinical employment of vitamin D analogs are growing and under active evaluation in different medical specialties, ranging from dermatology to immunology and oncology. In this review we provide a brief description of the drugs that have been developed more specifically for the treatment of secondary hyperparathyroidism (SH) associated ...
MAZZAFERRO, SANDRO +5 more
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The fields for clinical employment of vitamin D analogs are growing and under active evaluation in different medical specialties, ranging from dermatology to immunology and oncology. In this review we provide a brief description of the drugs that have been developed more specifically for the treatment of secondary hyperparathyroidism (SH) associated ...
MAZZAFERRO, SANDRO +5 more
openaire +3 more sources
The Function of Vitamin D Receptor in Vitamin D Action
Journal of Biochemistry, 2000Vitamin D has roles in a variety of biological actions such as calcium homeostasis, cell proliferation and cell differentiation to many target tissues. Most of these biological actions of vitamin D are now considered to be exerted through the nuclear vitamin D receptor (VDR)-mediated control of target genes.
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Vitamin D Analogs as Modulators of Vitamin D Receptor Action
Current Topics in Medicinal Chemistry, 2003The natural calcium-regulating hormone 1alpha,25-dihydroxyvitamin D(3) (1,25D(3)) is a secosteroid that offers organic chemists many sites for modifying structural and/or functional groups. Such modifications alter the chemistry, stereochemistry, and biological properties of the natural hormone.
Sara, Peleg, Gary H, Posner
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Vitamin D, Vitamin D Receptor, and Cathelicidin in the Treatment of Tuberculosis
2011Vitamin D plays a major role in bone mineral density and calcium homeostasis. Apart from its classical action, the active form of vitamin D [1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))] influences the innate and adaptive immune functions through vitamin D receptor (VDR) that are present in various cells of the immune system.
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Vitamin D/vitamin D receptor, autophagy, and infection.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022Vitamin D plays an important role in mineral and bone homeostasis, immune responses, cardiovascular function and keratinocyte proliferation and differentiation. Vitamin D performs most of its functions by binding to vitamin D receptors (VDR), which interact with other intracellular signaling pathways to regulate bone metabolism, inflammation, immunity,
Yu, Hou, Jinghui, Li, Chao, Deng
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Human prostatic urethra expresses vitamin D receptor and responds to vitamin D receptor ligation
Journal of Endocrinological Investigation, 2010Chronic inflammation is now considered a determinant of benign prostatic hyperplasia (BPH), promoting, together with the hormonal milieu, prostate overgrowth and lower urinary tract symptoms (LUTS). Prostatic urethra actively participates in determining progression of LUTS associated with BPH.To investigate the expression of the vitamin D receptor (VDR)
COMEGLIO, PAOLO +11 more
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