Results 51 to 60 of about 168,717 (262)

Bringing Vitamin D and the Vitamin D Receptor into the Limelight

Biomolecules
Classically, vitamin D is known to regulate skeletal and mineral ion homeostasis [...]
Jun Sun
doaj   +1 more source

Vitamin D and Skeletal Muscle: Current Concepts From Preclinical Studies

JBMR Plus, 2021
Muscle weakness has been recognized as a hallmark feature of vitamin D deficiency for many years. Until recently, the direct biomolecular effects of vitamin D on skeletal muscle have been unclear.
Christian M. Girgis, Tara C. Brennan‐Speranza   +1 more
doaj   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation

Frontiers in Immunology, 2020
Vitamin D was discovered 100 years ago and since then multiple studies have consistently proved its effect on bone health and mineral metabolism. Further research has also explored its so-called “non-classical” biological effects, encompassing immune ...
Jose Ros Soto, Chloe Anthias, Chloe Anthias, Alejandro Madrigal, John A. Snowden   +4 more
doaj   +1 more source

Vitamin D and vitamin D receptor polymorphism in Asian adolescents with primary dysmenorrhea

BMC Women's Health, 2023
Background The expression of vitamin D receptor in the normal endometrium and ovaries supports the role of vitamin D in local immunity and inflammatory cytokines regulation.
Ainur Donayeva, Ainur Amanzholkyzy, Roza Nurgaliyeva, Gulnara Gubasheva, Samat Saparbayev, Dinmukhamed Ayaganov, Aiman Kaldybayeva, Ibrahim A. Abdelazim, Mohamed M. Farghali   +8 more
doaj   +1 more source

MicroRNA regulates human vitamin D receptor [PDF]

International Journal of Cancer, 2009
AbstractMost of the biological effects of 1α,25‐dihydroxyvitamin D3 (1,25(OH)2D3) are elicited by the binding to vitamin D receptor (VDR), which regulates gene expression. Earlier studies reported no correlation between the VDR protein and mRNA levels, suggesting the involvement of posttranscriptional regulation.
Takuya, Mohri, Miki, Nakajima, Shingo, Takagi, Sayaka, Komagata, Tsuyoshi, Yokoi   +4 more
openaire   +2 more sources

An Ultrafast Self‐Gelling Versatile Hydrogel for Rapid Infected Burn Wound Repair in Military Medicine

Advanced Functional Materials, EarlyView.
A self‐gelling PG@PAC (POD/Gel‐CDH@PA/CHX) powder is developed for infected burn care in austere settings. Upon contact with wound exudate, it instantly forms an adhesive hydrogel, providing simultaneous hemostasis, broad‐spectrum antibacterial activity, reactive oxygen species scavenging, and immunomodulation. In a murine model of S.
Liping Zhang, Zhangrui Wu, Xiansheng Zhao, Geng Wang, Quyang Yang, Minxia zhang, Xiaowei Wang, Xiujun Cheng, Changyue Wu, Dan Wu, Yutian Yang, Canbin Dong, Tao Zhang, Weiqiang Tan, Ningwen Zhu   +14 more
wiley   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Vitamin D status, vitamin D receptor, CYP2R1, and CYP24A1 profiles in children

Frontiers in Nutrition
IntroductionVitamin D plays a major role in the musculoskeletal and immune system. Understanding the comprehensive mechanism of vitamin D receptors and the enzyme of vitamin D induction (CYP2R1) and inhibition (CYP24A1) in its metabolism is interesting ...
Anggraini Iriani, Andhika Rachman, Marsya Kaila Fatina, Rizka Kurnia Gemilang, Andi Trisnandi, Fiona Valerie Muskananfola, Media Fitri Isma Nugraha   +6 more
doaj   +1 more source